Although Dr. Goldstein claimed that the drugs he used were quite benign, the potential side effects of many of them are indeed quite nasty. And yet Goldstein claims that he never had a serious adverse drug reaction among any of his patients. Having read Betrayal of the Brain and being well into Tuning the Brain, I tend to believe him. He just knew how to use these drugs in a way that other people don't. It's also clear that he tended to overestimate the intelligence of other doctors from various stories he tells. In the case of his protocol, I wouldn't trust the average doctor to be able to use it safely. I've seen in this thread and elsewhere that people have said that he addressed only part of the picture. Yet at the beginning of Tuning the Brain, which was written shortly before his retirement, he claimed he had reached the point where he could make 97% to 98% of his patients completely asymptomatic, usually in a matter of days or less. In the case of some people who were doing some excellent work with IBS, he explained how both he and they could be getting good results using very different methods. He said that they were using a bottom up approach, while he was using a top down approach. I think that's true in general - he addresses the same issues that are discussed throughout this forum, but just approaches them all from the brain. If he got up to a 97% or 98% success rate, he had to be fixing methylation issues (which he briefly mentions, and to which he devotes a color plate), since they're so common in ME/CFS. The same also goes for immune system issues, endocrine issues, etc. As for infections, he acknowledged the need for antibiotics for acute infections; for herpes infections, he used Zantac,which usually resolved them in a day or two. (Yes, Zantac - for details, see this post and following.) Fixing the immune system addressed many low-grade infections. So I really do think he addressed the whole picture of ME/CFS. I don't think it's really sideways - Dr. Goldstein's philosophy seemed to be to do what worked. He noted that different patients often had the exact opposite effect to the same medication. Some of these differences he could explain; some of them he couldn't. If your ATP were being reduced substantially by this drug, I can't see how you would be feeling good. A drug that has the combination of making you feel good and also sleep better is very hard to find. If it's not decreasing your energy or giving you any other significant side effects, I would see no reason to stop it.