Glad you mentioned about taking calcium - didn't know that had anything to do with histamine response. I have only focused on magnesium, and didn't bother taking calcium. I finally put all of my daily supplements in one container, so will add the calcium. How much do you take a day? Also - do you think that the bad fatigue and blue mood have anything to do with the methylation response? I don't know what the heck is going on with myself. I'm also doing Andy Cutlers ALA protocol - 100 mg. ALA every 3 hours.