Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Australian researchers show that CFS is linked to a faulty cell receptor in immune cells

Discussion in 'Latest ME/CFS Research' started by keenly, Jul 10, 2017.

  1. keenly

    keenly Senior Member

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    'The breakthrough came after researchers from Griffith University identified that patients with CFS/ME were far more likely to have single nucleotide polymorphisms - DNA typos - in the genetic code for certain cell receptor.

    This cell receptor is known as transient receptor potential melastatin 3 (TRPM3), and in healthy cells it plays a crucial role - transferring calcium from outside the cell to the inside, where it helps regulate gene expression and protein production.'

    http://www.sciencealert.com/one-of-...t-chronic-fatigue-syndrome-just-got-destroyed
     
  2. Alvin2

    Alvin2 If humans were rational...

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    Fascinating though i am not convinced (yet).
    I thought Ron Davis already concluded this condition is not genetic, though of course that is subject to reanalysis.


    Also why does it emerge suddenly, that could be evidence either way though, genetic until triggered. Why do some people recover, the rate is low but does happen, though we cant be sure they actually have ME/CFS.

    The need for more research is clearly indicated.
     
  3. Manganus

    Manganus Senior Member

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    Canary islands
  4. keenly

    keenly Senior Member

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    I do not believe it is genetic.
    I do know calcium efflux is a major part of CFS. The reason you are always deficient is that intracellular
    magnesium needs ATP dependent membrane pumps to keep magnesium levels inside the cell normal. In a low energy state, magnesium leaks out of the cell and thence into the urine. In addition, calcium signaling ions cannot be pumped out of the cell which is potentially catastrophic to energy production and calcium balance. Low magnesium levels inside CNS cells make it impossible to sleep well and will cause sensory overload and anxiety disorders as well as seizures in the worst cases.
     
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  5. lansbergen

    lansbergen Senior Member

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    It could be. They say the receptors get upregulated with all kind of stressors.
     
  6. lansbergen

    lansbergen Senior Member

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    A certain stressor.
     
  7. keenly

    keenly Senior Member

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    Okay partially genetic, but with a stressor to set it off?
     
  8. lansbergen

    lansbergen Senior Member

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    Could be
     
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  9. keenly

    keenly Senior Member

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  10. Skippa

    Skippa Anti-BS

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    Calcium uptake seems to raise its head a fair bit...
     
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  11. Alvin2

    Alvin2 If humans were rational...

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    How do we know this?

    I'm not at all convinced of this, interestingly acetylcholine affects sleep in ways not at all researched, i have personal experience with this as well as other not journal published experience. This also jibes with the pyruvate dehydrogenase block theory. That said the whole picture is not yet available so like the magnesium statement its hard to say if what i am proposing is the actual mechanism, part of it, downstream or even related at all.

    Probably, what is the billion dollar question
     
  12. alicec

    alicec Senior Member

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    There has already been considerable discussion on PR about this and other studies from this group, as the search results show.

    The claim that there is a genetic basis to some of their observations has no substance. It is based on a very small (too small for statistical significance) study using inadequate statistics, discussed here. When the appropriate statistics were used by the authors themselves, the so-called differences disappeared.

    That second study is discussed here.
     
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  13. keenly

    keenly Senior Member

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    I know. I have already acknowledged this.
     
  14. pattismith

    pattismith Senior Member

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    This conditions is not genetic means that you can't find one gene mutation that could match to the disease....
    But most diseases are related to genes/epigenetic that predispose people to suffer from it.

    One snp that gives an increased risk for a disease by 3 or 6 doesn't make it a genetic condition,
    it is not a fatality, and recovering is still possible.
     

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