@TedBakerBoy The energy and good feeling you get from prednisone I have experienced. Here is my amalgam of personal experience, research and hyposthesis.
The adrenal gland produces cortisol a corticosteroid hormone to turn down the immune system when one is getting better from an illness. Like the army commander (adrenal glands) gets the word that the enemy has fallen, thus fighting should cease and resources be directed elsewhere and so they produce cortisol to accomplish this.
You may notice that when you become ill you feel tired, weak and often lose your appetite. The signal which causes this is preventing you from over expending your resources when they are needed to fight infection for survival.
When your adrenals get the all clear, they produce the corticosteroid which reverses the situation - now you feel energy, hunger and optimism even euphoric confidence. As your body is no longer fighting an infectious enemy, your body gets the message it is now ok to hunt, fight, and eat.... as your immune system activity drops.
So, by taking a corticosteroid you are overriding your body's decision and sending the message for the immune system not to fight. Clearly it might not be a good idea to send that message.
If for example, you are having a chronic reaction like asthma to mold in your home that you don't know about, you may initially feel better upon taking corticosteroids. But the mold is still there and you should be getting rid of it, or getting a new home because that is an enemy you don't want in your body. So taking a corticosteroid can send a false message, adding further problems and allowing the original problem to snowball. But the doctors don't usually tell you to look for mold or another problem, they just give out the corticosteroids.
In my situation - I had an extremely violent infection and afterwards, my immune system did not turn off but remained hyperactive to the point of hives and throat swelling almost shut. After months of seeing different doctors I finally ended up on corticosteroids which calmed my immune system. That was an emergency situation and the short term use of corticosteroids saved my life. My ANA levels, which had gone very high returned to normal. They should have tapered me off the steroids within a couple of weeks to see if my body had restored normal function. But the doctor never tried to take me off the steroids, which was a huge mistake that caused much serious damage to me, nearly costing me my adrenal function which you need to live.
Since corticosteroids lower your immune function thus I became susceptible to all diseases and I caught them, could barely recover, and became chronically ill in a downward spiral. I finally managed to get off the corticosteroids - which is a major feat not easily done. At least I am alive to tell you, there are many that are not so lucky.
Later, trying to figure out why my immune system went haywire, I later discovered that I was largely deficient in vitamin A. Having corrected that deficiency, I have found that my immune system has normalized.
Pharmaceutical corticosteroids like prednisone have a longer half life in the body than the natural cortisol your body produces. That interrupts the negative feedback system that the HPA axis operates on. Since the system no longer gets the message to tell the adrenals to produce the adrenals gradually atrophy and there is no guarantee that function will recover.
So while corticosteroids may make you feel better it often does not solve the real problem but makes things worse.