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Freddd's protocol helped me for a while with many things.
I did high dose methylcobalamin, methylfolate, and adenosylcobalamin with co-factors. Eventually one day, I went into a severe agitation/rage/excitotoxic state after taking 30mg b12+30mg folate, 10mg adeno and 200mg of SAM-e. I was hospitalized from this and only benzos relieved the distress. This indicates that high glutamate and excitotoxicity is causing this, as RichVanK said. I also lost my appetite completely.
Months later, if I take even 1mg of Methyl-B12 these symptoms come back.
It seems that I do need to fix my methylation, as when I discontinue everything I develop major depression and become non-functional. I have multiple chemical sensitivities, anxiety, and brain fog as well.
Can someone please help me with this? Will hydroxocobalamin be good for me; will it cause agitation in me?
Gene SNPs
COMT V158M rs4680 AA +/+
COMT H62H rs4633 TT +/+
MAO A R297R rs6323 T +/+
MTHFR C677T rs1801133 AA +/+
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MTRR K350A rs162036 AG +/-
MTRR A664A rs1802059 AG +/-
BHMT-02 rs567754 CT +/-
AHCY-01 rs819147 CT +/-
AHCY-19 rs819171 CT +/-
Detox Profile
CYP1B1 L432V rs1056836 GG +/+
GSTP1 I105V rs1695 GG +/+
GSTP1 A114V rs1138272 TT +/+
SOD2 A16V rs4880 GG +/+
CYP1A2 164A>C rs762551 AC +/-
CYP1B1 N453S rs1800440 CT +/-
CYP1B1 R48G rs10012 CG +/-
CYP2C19*17 rs12248560 CT +/-
CYP2D6 S486T rs1135840 CG +/-
CYP2D6 2850C>T rs16947 AG +/-
CYP3A4*1B rs2740574 CT +/-
NAT2 R197Q rs1799930 AG +/-
I did high dose methylcobalamin, methylfolate, and adenosylcobalamin with co-factors. Eventually one day, I went into a severe agitation/rage/excitotoxic state after taking 30mg b12+30mg folate, 10mg adeno and 200mg of SAM-e. I was hospitalized from this and only benzos relieved the distress. This indicates that high glutamate and excitotoxicity is causing this, as RichVanK said. I also lost my appetite completely.
Months later, if I take even 1mg of Methyl-B12 these symptoms come back.
It seems that I do need to fix my methylation, as when I discontinue everything I develop major depression and become non-functional. I have multiple chemical sensitivities, anxiety, and brain fog as well.
Can someone please help me with this? Will hydroxocobalamin be good for me; will it cause agitation in me?
Gene SNPs
COMT V158M rs4680 AA +/+
COMT H62H rs4633 TT +/+
MAO A R297R rs6323 T +/+
MTHFR C677T rs1801133 AA +/+
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MTRR K350A rs162036 AG +/-
MTRR A664A rs1802059 AG +/-
BHMT-02 rs567754 CT +/-
AHCY-01 rs819147 CT +/-
AHCY-19 rs819171 CT +/-
Detox Profile
CYP1B1 L432V rs1056836 GG +/+
GSTP1 I105V rs1695 GG +/+
GSTP1 A114V rs1138272 TT +/+
SOD2 A16V rs4880 GG +/+
CYP1A2 164A>C rs762551 AC +/-
CYP1B1 N453S rs1800440 CT +/-
CYP1B1 R48G rs10012 CG +/-
CYP2C19*17 rs12248560 CT +/-
CYP2D6 S486T rs1135840 CG +/-
CYP2D6 2850C>T rs16947 AG +/-
CYP3A4*1B rs2740574 CT +/-
NAT2 R197Q rs1799930 AG +/-
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