garyfritz
Senior Member
- Messages
- 599
Can anyone offer any insights on my fairly huge requirement for B12?
My B12-deficiency symptoms are not nearly as bad as what many of you suffer through, but they make life absolutely miserable if I don't keep pumping the B12. During the day I have skin-crawling sensations, fasciculations, very unpleasant tingling in my legs, RLS, fight-or-flight-like agitation, etc. At night I wake with tensed and twitching muscles, agitation, nightmarish mental state. Before I discovered B12 the twitching was increasing to near-siezure-like thrashing that I really couldn't control. I was only getting 2-3 hours of fitful sleep per night, and I was a basket case.
Thankfully I can keep the symptoms pretty much under control with B12. I'm using a triple dose of the Australian transdermal oil. If you believe their (animal-testing-documented) claim of 80% absorption, that says I've been taking the equivalent of injecting about 2mg/day methylB12 and 5-6mg/day adenosylB12. And lately I've been requiring more than that. Furthermore I don't seem to store any reserves of B12, since the symptoms pop up within hours if I miss a dose or reduce my dosage. Either I lack the ability to store excess B12, or even this amount of B12 isn't enough for me to HAVE any excess.
What could cause such an insatiable demand for B12? What supplementation could I add that would help my body make efficient use of the ridiculous amount of B12 sloshing around in my veins? Is there some way I can make the Intrinsic Factor work more efficiently?
Also, why would I have a higher demand for B12 at night? I can take a single dose in the morning and my symptoms are usually controlled for 12-15 hours. Then I take a double dose at bedtime, and the symptoms often pop up again within 2-4 hours. I tried cutting back to one dose at bedtime and I was consistently awake and vibrating within a few hours.
My SNPs are below. I already take a broad variety of vitamins and supplements, including methyl folate and a range of B vitamins.
Thanks for any suggestions...
Gary
My B12-deficiency symptoms are not nearly as bad as what many of you suffer through, but they make life absolutely miserable if I don't keep pumping the B12. During the day I have skin-crawling sensations, fasciculations, very unpleasant tingling in my legs, RLS, fight-or-flight-like agitation, etc. At night I wake with tensed and twitching muscles, agitation, nightmarish mental state. Before I discovered B12 the twitching was increasing to near-siezure-like thrashing that I really couldn't control. I was only getting 2-3 hours of fitful sleep per night, and I was a basket case.
Thankfully I can keep the symptoms pretty much under control with B12. I'm using a triple dose of the Australian transdermal oil. If you believe their (animal-testing-documented) claim of 80% absorption, that says I've been taking the equivalent of injecting about 2mg/day methylB12 and 5-6mg/day adenosylB12. And lately I've been requiring more than that. Furthermore I don't seem to store any reserves of B12, since the symptoms pop up within hours if I miss a dose or reduce my dosage. Either I lack the ability to store excess B12, or even this amount of B12 isn't enough for me to HAVE any excess.
What could cause such an insatiable demand for B12? What supplementation could I add that would help my body make efficient use of the ridiculous amount of B12 sloshing around in my veins? Is there some way I can make the Intrinsic Factor work more efficiently?
Also, why would I have a higher demand for B12 at night? I can take a single dose in the morning and my symptoms are usually controlled for 12-15 hours. Then I take a double dose at bedtime, and the symptoms often pop up again within 2-4 hours. I tried cutting back to one dose at bedtime and I was consistently awake and vibrating within a few hours.
My SNPs are below. I already take a broad variety of vitamins and supplements, including methyl folate and a range of B vitamins.
Thanks for any suggestions...
Gary