Zinc transporter on Promethease APP

[aquariusgirl]

Hi, the updated version of Promethease has flagged a zinc transporter for me. Says it's associated with diabetes. Wondering if others have seen this? I am C/C for this Snp.

rs13266634 is a SNP in the zinc transporter protein member 8 SLC30A8 gene that has primarily been associated with type-2 diabetes in several studies. This SNP is also known as the Arg325Trp or R325W variant; the (C) allele encodes the arginine (R), and the (T) allele encodes the tryptophan (W)

 

[Ravn]

C/C
Do any of the more science-literate members know the importance (or otherwise) of this?

 

[alicec]

C/C is the wildtype or ancestral allele and the most common with a frequency of about 0.715.

In other words that variant is protective so the normal allele becomes "risk".

Since the protein is a zinc transporter it suggests that the variant may do a better job of getting zinc where it is needed.

Here is a paper which suggests that the T2D risk may be reduced by high zinc intake and high zinc to iron intake.