So as the replication studies are under way, i wonder what needs to be demonstrated to prove that XMRV is responsible to cause CFS ? Is this an important part of research ?
If you go to the post I made called 'HERVs and XMRV' on this same subforum, the link Kurt posts on "Rumor Viruses" has a section on criteria for establishing causality for retroviruses in illnesses.
Also, for general purposes: Bradford-Hill criteria: