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XMRV - Current Research Program


Senior Member
United Kingdom
I found this information on the WPI website, So Everyone please sleep well tonight, we're being looked after! :Retro smile:

Current Research Program

Role of Chronic Inflammatory and Immune Stimulation by Active Herpesvirus Infection in the Development of Immune Dysfunction in CFS
Studies of immune abnormalities in this CFS cohort will involve phenotypic analysis of NK, DC, and T cell populations. States of activation and differentiation will be studied to determine whether the cells are immune activators or suppressors due to response to infection. The goal is to understand the imbalance in the immune system that leads to unregulated virus expression.
Collaborators: Francis Ruscetti, PhD, NIC, Dennis Taub PhD, NIA (INIP Research Award)

Novel Viruses/Co-infections in Subgroups of CFS
A Virus DNA Microarray (Virochip) was used to screen a cohort of CFS with Immunological defects and increased incidence of Mantle cell lymphoma (MCL).
Collaborators: Francis Ruscetti, PhD, Cancer Inflammation Program, NCI

Role of the Interferon/RNaseL Antiviral Pathway in CFS
The goal of this study is to characterize defects in the Interferon/RNaseL antiviral pathway which result in viral persistence.
Collaborators: Robert Silverman, PhD, Cleveland Clinic

Role of Inflammatory Cytokines and Chemokines in CFS
The purpose of this study is to identify and develop the serum biomarker patterns of cytokine and chemokines, which correlate with clinical disease and can be used to monitor intervention.
Collaborators: Dennis D. Taub, PhD, NIA

Host Susceptibility in CFS
The goal of this study is to elucidate genetic factors of susceptibility and the dysregulation of the host defense system in order to develop biomarkers for diagnostic development and thus predict response to immune modulating therapy and vaccines.
Collaborators: Jonathan R. Kerr, MD, PhD, St. Georges University, London UK,
Mary Carrington, PhD, NCI, Mike Dean, PhD, NCI

Enumeration and Function of Natural Killer (NK) Cells in CFS
The purpose of this project is to develop improved NK diagnostic tests for both the number and function of NK cells.
Collaborators Doug Redelman, PhD, UNR, Dept. of Microbiology & Immunology

Epidemiologic Evaluation of Lymphoma and Cancer Incidence in Nevada CFS Cohort
The goal of this study is to determine if a possible cancer cluster exists in the cohort of Nevada CFS patients.
Collaborators: Paul Levine, MD, George Washington University

Study of Clonal T Cell Receptor-gamma Rearrangements in Nevada CFS Cohort
The purpose of this study is to determine the significance of clonal T cell receptor-gamma rearrangements in the pathogenesis of CFS.
Collaborators: Dorothy Hudig, PhD, UNR, Dept. of Microbiology & Immunology

Development of a Whole Genome Transcriptome Assay for HHV6
The goal is to develop a whole genome transcriptome assay for HHV6 and a sub array for HHV6A specific detection to be used as a diagnostic tool or research tool to understand the viral life cycle in disease.
Collaborators: Rachel Bagni, PhD, Applied Technology Program, NCI

HHV6 Latency in CFS

The goal of this study is to understand the role of HHV6A latency in bone marrow hematopoietic stem cells in the pathogenesis of CFS.
Collaborators: Stephen St. Joer, PhD
Marianna Bego, PhD, UNR, Dept. of Microbiology & Immunology


Senior Member
Thanks Villagelife.
It all sounds good, and look at who they are still working with. We climbing out of that gutter people. :victory:


Patient in training
This research program page has been there for months, nothing new. I would believe WPI would release the news if they got some grant money, that would be an event by itself.