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XMRV and RNAse studies in NZ


Senior Member
http://biochem.otago.ac.nz/Potential research projects 2010.pdf

Biochemistry 400-level
Honours, DipSci and MSc
indicative projects for 2010

Research areas for Biochemistry 400-level Honours, DipSci and MSc projects
for 2010 are summarised in this handout. Further details will be provided at
the beginning of the new semester in February next year. During the first
week of the semester staff are available to discuss potential projects.

Typically one 400-level Honours or DipSci student is assigned to one lab.
The lab assignments are made at the end of the first week of the semester.
If you are interested in a two-year MSc then you are advised to contact the
potential supervisors in February 2010.

More information on the research interests of individual staff members can
be found on the Biochemistry Department's website:


Chronic Fatigue Syndrome:
XMRV as a potential cause of chronic fatigue syndrome

Supervisor: Professor Warren Tate

Currently there is no diagnostic test for Chronic Fatigue Syndrome (CFS)
although millions world wide are affected with the syndrome. A very recent
Science paper (9.10.09) has linked CFS with a rodent retrovirus XMRV (rather
like HIV-1) that can as well cause aggressive prostate cancer. About 70% of
the affected group had evidence of the virus compared with only 4% of the
control population. My lab has done developmental work on a rogue
RNAse L cleavage fragment for a biomarker since it is claimed to be specific
for CFS and indirectly to deplete affected cells of 50% of their ATP. We
would like to examine the virus and its translational mechanisms as a
potential drug target and establish the RNAse L fragment as a biomarker.


Thanks for posting this research news.

It interested me that Dr Mikovits in her talk from last week did mention there is something wrong with the RN-aseL in CFS patients.
(This was known over a decade ago), but rarely talked about. Now Dr Peterson and Dr Mikovits have mentioned it again this year in the light of discovery of XMRV.

For anyone interested in RN-aseL in themselves a test is available from Europe and also America.