Well, someone mentioned XMRV can infect CNS cells.
Many people have high cortisol in the early stages of illness. In fact, many describe high activity levels, two jobs, difficult emotional time, stressful job, type A go getters, before they crash.
So, this cortisol / adrenaline saturated life, along with progesterone spikes, or another virus or vaccine, suddenly pushes virus load high enough that person does not have enough NK Cells to hold back co-infections, and then the inflammation starts, and the cycle begins. But the cortisol is spent, so we are low. Or the CNS is now infected causing hormone block so that message is not getting to adrenals to release cortisol.
Of course, some of us have good days and bad days. So on bad days, our body is storing up, healing. So on our good day, we required cortisol, and it puts out. But that causes another increase in virus replication, causing co-infections to flourish, causing inflammation, causing a bad day within 24 hours.
Isn't Klimas doing a good day / bad day study.