Whats the most sensitive and best borrelia test?
I have done to lumbar punctures looking specifically for borrelia but both were negative. They were taken years after symptom start.Physical examination 🖖
For late stage lyme it's tricky...
For Neuroborrelia it's the liquor/serum pair... Lumbar puncture plus blood draw
igenex has notoriously high false positive rates if you use their in house bands (50% false positive
This gets repeated again and again but it's not very accurate information.
First of all, what is a "false positive" when there is no gold standard test?
Second, they updated their in-house criteria in response to that criticism. It was many years ago.
Third, there are many reasons why a "standard" Western Blot from a non-specialty lab can be totally useless.
I am all for criticism, and I have a lot of criticism of the Lyme world myself. But iGenex is probably the least shady of the labs, and also has the best ability to detect coinfections such as Babesia.
I suppose one could criticize this presentation for including information that is not published and peer-reviewed.
But if I was sick and suspected Lyme Disease, I'd want to get these tests.
A false positive is when they get general population tested as controls to sick people with clinical diagnosis and its the same rates.First of all, what is a "false positive" when there is no gold standard test?
Is there any data on the titers of sick patients anywhere?A false positive is when they get general population tested as controls to sick people with clinical diagnosis and its the same rates.
There isnt a perfect test in existence. And lyme is horrible and too little is known about it. But this doesn't mean we should throw out scientific standards and let private expensive quack laboratories and doctors prey on us. igenex has shown in no way that their test is superior to the CDC standard , and at least one well done study has shown that it is far worse.
The onus is really on them to show its accuracy with good control and non control groups.
I didnt know that the benefits could be from lowering glutamate. Could you link to that positive study?My illness started with lyme and for awhile I tried tons of antibiotics and then lyme herbs and all the crap that llmds push. Finally I realized the simplest explanation was the most correct. That all infectious diseases cause similar sequelae and syndromes and that this doesnt have to be due to an active infection. But even if it is due to an active infecrion , the studies for abx treatment of chronic lyme look very underwhelming. Like one slightly positive one and four negatives. And the positive one could be just from lowering glutamate.
@Hip has noted that that class of antibiotics, beta lactam antibiotics, can lower brain glutamate. He has it somewhere. I dont know the specific study offhand bc it's just one of a million things about the illness I remember and not in my top few most important. They used iv ceftriaxone and got improvements in brain fog or cognitive fatigue in post lyme patients.didnt know that the benefits could be from lowering glutamate. Could you link to that positive study?