What does your SHBG levels look like?

[drob31]

My SHBG levels are always high causing my free test to be low normal, which is a huge factor in energy levels. Recently I've been investigating the connection between prolactin, dopamine, and SHBG. It seems the more I lower prolactin, the higher dopamine, and the lower SHBG levels go.


Magnesium and Boron seem to lower SHBG a little.

B6 and Sam-e seem to lower prolactin a little. But when you combine them, they seem to have a larger impact overall on lowering SHBG and raising free testosterone.

Sometimes the cause of high SHBG is the liver, and Sam-e not only improves methylation but also liver function, and this increase SHBG clearance.

 

[Gondwanaland]

Last time I tested SHBG one year ago it was above range. I would be interested in alternatives to SAMe since it is quite expensive and I am not sure I can get it locally. Additionally, anything-methionine gives me horrible brain fog.

I tested prolactin 2 years ago and it was very low in range.

 

[Thinktank]

My SHBG is high, but i also have plenty testosterone. Free testosterone is low-normal.
I probably also have high prolactin because i suffer a bit from gynecomastia, although high prolactin does not show up on testing. Dopamine is probably low in me.

Ref. range nmol/L 0,198 - 0,618 // Free testosteron (calculated) = 0,302
Ref. range nmol/L 18,3 - 54,1 // SHBG = 79,5
Ref. range µg/L 4,0 - 17,0 // Prolactin = 4,4
Ref. range nmol/L 8,68 - 29,15 // Testosterone = 25,50

 

[drob31]

Last time I tested SHBG one year ago it was above range. I would be interested in alternatives to SAMe since it is quite expensive and I am not sure I can get it locally. Additionally, anything-methionine gives me horrible brain fog.

I tested prolactin 2 years ago and it was very low in range.

I think this might have more of an affect on males.

 

[drob31]

My SHBG is high, but i also have plenty testosterone. Free testosterone is low-normal.
I probably also have high prolactin because i suffer a bit from gynecomastia, although high prolactin does not show up on testing. Dopamine is probably low in me.

Ref. range nmol/L 0,198 - 0,618 // Free testosteron (calculated) = 0,302
Ref. range nmol/L 18,3 - 54,1 // SHBG = 79,5
Ref. range µg/L 4,0 - 17,0 // Prolactin = 4,4
Ref. range nmol/L 8,68 - 29,15 // Testosterone = 25,50

I speculate, that things that raise prolactin, such as having an orgasm, cause a way larger / longer spike in prolactin. Measuring it in the morning would reveal normal levels.

 

[heapsreal]

Did you get E2/estrogen tested as high levels can increase shbg in men. Balance to get the e2 right as too high and too low can cause problems.

 

[pamojja]

It seems the more I lower prolactin, the higher dopamine, and the lower SHBG levels go.

Though not consistently tested, can't particularly recognize such an association in my results:

Year   Prol  SHBG  tTest fTest Estr 25(OH)D
      µg/dl nmol/l ng/dl pg/ml pg/ml ng/ml
2010    -      -    400    -    51    63
2011   4.8     -    200    -   <10    44
2012    -      -    262   5.4   24    62
2013    -      -    320    -     -    84
2014   6.6    53    340   4.9   32    51
2015  10.5    57    351   5.9   21    78
2016   8.1    77    469   9.3   46    72
2017    -      -      -    -     -    79
Oct.9   -    122    617   8.3   17   135
Oct.17  -    108    646   8.7    -   111

Oct. 9th test results have been lost and therefore retested. Later a technician could retrieve these earlier results from databases. Added 25(OH)D because it's association with the decline in SHBG.

Magnesium and Boron seem to lower SHBG a little. ..B6 and Sam-e seem to lower prolactin a little. ...Sometimes the cause of high SHBG is the liver, and Sam-e not only improves methylation but also liver function, and this increase SHBG clearance.

Also have been taken 2.4 g/d of elemental Mg, 9 mg/d of Boron and 160 mg/d B6 this year. Only a humble dose of 90 mg/d of SAMe discontinued at the beginning of this year. And my liver enzymes indeed rose to the higher end of normal ranges in the Oct. 9th results, decreasing already a week later in average by 10 points each.

Resting heard-rate lowered for the first time to 72 (before 77 in avg. for many years) Lowest inflammation markers in long times. Not that I actually felt anything different..

 

[drob31]

Orgasm and exersize are what I think may lead to abnormal prolactin spikes. B6 + Sam-e would combat this.