Violeta
Senior Member
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https://pubmed.ncbi.nlm.nih.gov/36450257/
Metabolic rewiring is essential for Th17 cells' functional identity to sense and interpret environmental cues. However, the environmental metabolic checkpoints with specific regulation of Th17 cells, manifesting potential therapeutic opportunities to autoimmune diseases, remain largely unknown. Here, by screening more than one hundred compounds derived from intestinal microbes or diet, we found that vitamin B5 (VB5) restrains Th17 cell differentiation as well as related autoimmune diseases such as experimental autoimmune encephalomyelitis and colitis. Mechanistically, VB5 is catabolized into coenzyme A (CoA) in a pantothenate kinase (PANK)-dependent manner, and in turn, CoA binds to pyruvate kinase isoform 2 (PKM2) to impede its phosphorylation and nuclear translocation, thus inhibiting glycolysis and STAT3 phosphorylation. In humans, reduced serum VB5 levels are found in both IBD and MS patients. Collectively, our study demonstrates a role of VB5 in Th17 cell metabolic reprograming, thus providing a potential therapeutic intervention for Th17 cell-associated autoimmune diseases.
I woke up with a terrible headache and postherpetic neuralgia and itchy eyes were the worst they have been in a long time.
I tried testing to see if anything that I have in my walk-in closet of supplements and herbal remedies. Couldn't find anything.
Finally started to try B vitamins. First tried B2, it nearly knocked me over backwards. So I tried B5, finally something that would help.
So I looked up B5 with autoimmunity and this study was the first to come up.
I could hardly believe it had PKM2 in the title!
Remember this study?
So B5 may help with this.
I have been depending on dairy for protein, and I think I have come up lacking in B5, B6, and B3.
Metabolic rewiring is essential for Th17 cells' functional identity to sense and interpret environmental cues. However, the environmental metabolic checkpoints with specific regulation of Th17 cells, manifesting potential therapeutic opportunities to autoimmune diseases, remain largely unknown. Here, by screening more than one hundred compounds derived from intestinal microbes or diet, we found that vitamin B5 (VB5) restrains Th17 cell differentiation as well as related autoimmune diseases such as experimental autoimmune encephalomyelitis and colitis. Mechanistically, VB5 is catabolized into coenzyme A (CoA) in a pantothenate kinase (PANK)-dependent manner, and in turn, CoA binds to pyruvate kinase isoform 2 (PKM2) to impede its phosphorylation and nuclear translocation, thus inhibiting glycolysis and STAT3 phosphorylation. In humans, reduced serum VB5 levels are found in both IBD and MS patients. Collectively, our study demonstrates a role of VB5 in Th17 cell metabolic reprograming, thus providing a potential therapeutic intervention for Th17 cell-associated autoimmune diseases.
I woke up with a terrible headache and postherpetic neuralgia and itchy eyes were the worst they have been in a long time.
I tried testing to see if anything that I have in my walk-in closet of supplements and herbal remedies. Couldn't find anything.
Finally started to try B vitamins. First tried B2, it nearly knocked me over backwards. So I tried B5, finally something that would help.
So I looked up B5 with autoimmunity and this study was the first to come up.
I could hardly believe it had PKM2 in the title!
Remember this study?
PKM2 accelerated the progression of chronic fatigue syndrome via promoting the H4K12la/ NF-κB induced neuroinflammation and mitochondrial damage
So B5 may help with this.
I have been depending on dairy for protein, and I think I have come up lacking in B5, B6, and B3.