- Messages
- 50
Earlier this year, from March to April I was taking vitamin A in the form of retinyl palmitate at a dose of 10,000 ius in a foolish attempt to see if it would help my acne. (I tested my blood and was right at the lower limit) I was unaware of the face that retinyl palmitate upregulates the enzyme GNMT which can lead to hypomethylation.
Here are some articles on the topic:
https://www.researchgate.net/profil...patic-Glycine-N-Methyltransferase-in-Rats.pdf
https://molmed.biomedcentral.com/articles/10.2119/molmed.2010.00243
Rick was also aware of this and discussed the topic in this thread:
https://forums.phoenixrising.me/threads/roaccutane-caused-depression-isotretinoin.12117/
This resulted in the worst few months of my life in terms of how I was feeling. I started having episodes of dizzy spells, anxiety, shortness of breath, numbness, lost 10 pounds, and a bunch of other issues. The doctors did a ton of tests and told me everything was fine.
They asked me what supplements I had been taking and the only thing new was the vitamin A. We tested my levels to see if I had vitamin A toxicity and I was surprised to see that after months of taking a high dose, that my levels had decreased drastically and I had become even more deficient. This is when I realized maybe my body did not want the vitamin A and got rid of it as a protective measure?
My doctor is telling me to take the vitamin A because it was likely not what caused me to feel this way and being deficient can impact my vision and other things. (I started to say a few things about my theory and methylation but she looked at me like I was crazy). Obviously I do not want my vision to take a toll but I am almost 100% certain the vitamin A caused this.
Other supplements I was taking at the time were methylfolate, methylb12, iron, fish oil, and creatine. I have taken all of these over the years without any issue (aside from the creatine which was several months new as well but found no research that this could cause an issue).
Now, when I try to take any of my supplements I feel extremely fatigued and short of breath. If I continue to try to take them I start to get the weird episodes again.
Apparently GNMT is supposed to be inhibited by folate but when I take it now, I feel terrible. Rick also said this in the linked thread but that taking folate did not help other individuals either. He was not sure how to fix it.
I was hoping someone who knows more about methylation than I do could look into this and the role of GNMT in the methylation cycle. If you have any ideas, please let me know. The episodes and worst of it have stopped but I am still losing weight and feel fatigued.
I was wondering if it might have something to do with b12 since both b12 and GNMT have a role in methionine metabolism.
Thanks for your time if you read all this.
Here are some articles on the topic:
https://www.researchgate.net/profil...patic-Glycine-N-Methyltransferase-in-Rats.pdf
https://molmed.biomedcentral.com/articles/10.2119/molmed.2010.00243
Rick was also aware of this and discussed the topic in this thread:
https://forums.phoenixrising.me/threads/roaccutane-caused-depression-isotretinoin.12117/
This resulted in the worst few months of my life in terms of how I was feeling. I started having episodes of dizzy spells, anxiety, shortness of breath, numbness, lost 10 pounds, and a bunch of other issues. The doctors did a ton of tests and told me everything was fine.
They asked me what supplements I had been taking and the only thing new was the vitamin A. We tested my levels to see if I had vitamin A toxicity and I was surprised to see that after months of taking a high dose, that my levels had decreased drastically and I had become even more deficient. This is when I realized maybe my body did not want the vitamin A and got rid of it as a protective measure?
My doctor is telling me to take the vitamin A because it was likely not what caused me to feel this way and being deficient can impact my vision and other things. (I started to say a few things about my theory and methylation but she looked at me like I was crazy). Obviously I do not want my vision to take a toll but I am almost 100% certain the vitamin A caused this.
Other supplements I was taking at the time were methylfolate, methylb12, iron, fish oil, and creatine. I have taken all of these over the years without any issue (aside from the creatine which was several months new as well but found no research that this could cause an issue).
Now, when I try to take any of my supplements I feel extremely fatigued and short of breath. If I continue to try to take them I start to get the weird episodes again.
Apparently GNMT is supposed to be inhibited by folate but when I take it now, I feel terrible. Rick also said this in the linked thread but that taking folate did not help other individuals either. He was not sure how to fix it.
I was hoping someone who knows more about methylation than I do could look into this and the role of GNMT in the methylation cycle. If you have any ideas, please let me know. The episodes and worst of it have stopped but I am still losing weight and feel fatigued.
I was wondering if it might have something to do with b12 since both b12 and GNMT have a role in methionine metabolism.
Thanks for your time if you read all this.