Could this be a sign of infection?
When the valtrex kills the replicating viruses, you may get some immune recognition of the EBV, leading to some lymph node swelling and symptoms.
The inhibitors of protease (ritonavir, atazanavir and darunavir), viral DNA polymerase (acyclovir, tenofovir, valganciclovir and valacyclovir) and of integrase (raltegravir) are listed among the Top 200 Drugs by sales during 2010s.
Getting "die-off" symptoms or "herxing" from valtrex or other herpes antivirals, doesn't make sense to me. Because valtrex works by stopping viruses from multiplying, by inhibiting viral DNA polymerase, it doesn't kill them
So there can't be die-off because the viruses live their normal life-span, they just are unable to replicate and multiply, therefore lowering the viral load. This is one reason why I think antivirals work in some other way to help some us, rather than lowering viral loads.
At least this is how I understand how herpes antivirals work.
My thought is that, if you have viral DNA in a cell in various stages of replication, along with the viral proteins in various stages of completion and assembly, and you use a DNA polymerase inhibitor to halt that process, inclusive of a halt on the viral proteins that inhibit immune activation and B-cell apoptosis, you may get some immune recognition, B-cell apoptosis, and immune-mediated cell destruction.
My doctor said this is a common experience.
Thanks for Sharing. This is Very interesting. Did you measure your temperature confirming fever?I had a slight flair in my chronic lymph node swelling for 1-2 days after starting valaciclovir and then it subsided, along with my chronic sore throat, completely disappearing within a month or so. I also had a low-grade fever most of the time during my first month on valacyclovier.