I favor Famvir Acyclovir and Valtrex in that order.
Just to weigh in on this discussion briefly, I hwas taking Acyclovir and Valtrex for a few months without much success. But after hearing about the successes some PWMEs were having with Famvir I decided to try that as a replacement or occasional substitute for those gigantic Valtrex tablets. I noticed that the Famvir worked better than the Valtrex, although even taking all three -- and be careful not to damage your liver by taking too much that way! -- only reduces my pain fatigue and other problems about 20%. They wanted $47 per pill for Famvir at my local pharmacy here in the U.S.. So, I hunted around on the web and found that the cheapest Canadian price for them was, get this, only $208 delivered -- usually in about a week - for a a bottle of 100 500mg. tablets. That means I can take one tablet every day for only ~$60/month! Sometimes I do take two of them, just to see if it makes any difference, -- unfortunately, I'm not yet sure about that, since I've only done random days, not, say, a whole fortnight or two weeks -- but I will try the higher dose for that length of time soon and report the results here. I'm not sure whether I can mention the pharmacy with the lowest prices here or not. But I can certainly say, I trust, that I get them from "Langley, B.C.," near Vancouver, and that the place calls itself a "Discount Pharmacy" and considers itself to be located in the great "North West," like Seattle does, even though it is actually in the southwest of Canada. For you medical sleuths out there, the pharmacy also includes some of the words just cited here in its name.
Give them a try if you want, and if you don't have bad allergies or other sensitivities that might interfere with them. It's probably best to start with only a half or even just a quarter tab. Who knows, maybe you'll get a 30% relief from them, which, if you are anywhere near as ill as I've been since the end of 1990, should still make a big difference in how you feel and what you are able to do. I hope that this information of help to someone out there!! As for me, I'm going to bust open my piggy bank yet again -- I figure this disease has cost me more than a million dollars so far! -- and try to get into one of the new Retuximab trials already underway here in the U.S., even though I have heard widely conflicting reports about its efficacy in treating ME/CFS. But at 57, I have to try just about anything if I am going to have any chance of being healthy again and enjoying life a bit before whatever is ultimately fated to do me in altogether comes round with the Reaper man. Ah, but I should take heart, since I just read that Dr. Suess is now 108 and still going strong!