I found it quite interresting that rituximab happens to have interactions with a protein from a gene that stood out as hypermethylated in a mecfs twin study. Rituximab does help a small subgroup of patients and this means that it might not be because of the removal of autoantibodies.
Regarding the metals, i remember that part but wasnt able to find it rn. When i listened to it earlier i think i assumed this was just some epigenetic move made by the body instead of some type of poisoning or equivalent, not sure if thats right though.
This online article discusses micro RNAs and the role of metals....so its related generally to the discussion, and I'll need to take some time trying to read through it.
Cells 2020, 9, 901; doi:10.3390/cells9040901
Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development
The toxic effect of heavy metals such as cadmium (Cd), arsenic (As), lead (Pb), mercury (Hg), and manganese (Mn) is a matter of global concern.
Conclusions and Future Perspectives
Environmental and occupational exposure to toxic heavy metals can alter epigenetic regulatory signatures such as DNA methylation, histone modification, and microRNA (miRNA) expression patterns. miRNAs are endogenous, noncoding RNAs of approximately 25 nucleotides, which play fundamental gene-regulatory roles by binding to the 3′ UTR of protein-coding genes to mediate their post-transcriptional repression.....