mariovitali
Senior Member
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It's not so much that I think the entire treatments are necessarily BS. In fact, I personally find folate beneficial (taken as needed for avoiding migraines), and high doses of injected hydroxoB12 to be beneficial (for pain). There's probably things on the other protocols which I have taken in isolation and found some benefit from.I know from reading this thread that you feel Mario's protocol is BS, I can also see from this post that you think methylation disorders are BS.
So I'm wondering if you think that freddd's protocol is worthless? or is your objection more that there is no scientific explanation to support the idea of methylation disorders?
Tudca 250mg AM and PM
MethylB12 injections 5mg twice per week
Dibencozide 10mg QD - I just ran out of this so am discontinuing for now
5-MTHF 5mg QD
AlphaGPC 300mg QD
TMG 750mg QD
FMN 25mg QD
P-5-P 50mg QD
L-Tyrosine 500mg QD
Pycogenol 50mg AM and PM
Pantothenic Acid 500mg QD
Vit B-1 100mg QD
Biotin 10mg QD
Iodine 1.1mg QD
Selenium 100mcg QD
Ferrochel 27mg - I have chronically low ferritin if I don't supplement
Zinc Chelate 20mg QD
Magnesium Threonate 2000mr PM - helps me sleep
NAC Sustain 600mg PM
Melatonin 1mg PM
Levothyroxine 50mcg QD - been on this for several years
I'm also on TRT, tried to stop, but my insomnia got worse.
It's not so much that I think the entire treatments are necessarily BS. In fact, I personally find folate beneficial (taken as needed for avoiding migraines), and high doses of injected hydroxoB12 to be beneficial (for pain). There's probably things on the other protocols which I have taken in isolation and found some benefit from.
But the theories underlying those protocols have little or no substance. So while I have no problem with someone saying "Hey, B12 helped me", it's misleading to say "B12 will help you because you have these (actually meaningless) Yasko SNPs." It's incorrect and even dishonest to suggest that there is a scientific basis for most of the treatments proposed, and I object to that use of pseudoscience to "sell" the treatment protocol.
I don't want to say I have CFS, seems people on this forum get pretty upset when someone new comes on and claims to have CFS.OK, Thanks (Please go to the first page and notice that i was too Hypothyroid and had Hypogonadism. Do you have Subclinical Hypothyroidism?).
Some more questions :
-How did you get CFS? Did you -by any chance- took any Medication such as Cirpo/Finasteride/Accutane etc? Did you get it after an Epstein-Barr virus infection?
-How long do you have this condition?
-Do you have DNA Data available?
-Have you ever had Liver tests?
-Have you checked your Manganese Levels?
@792e31d6
Sorry, what is PEM exactly?
Regarding Manganese : It is a very important cofactor, why i am mentioning it is a rather big story.
It is unfortunate that you do not have your DNA Data...
FYI My regimen is as follows.
08:00 Dibencozide,FMN, Metafolin
10:00 Alpha GPC, Biotin,Pantothenic Acid
12:00 TUDCA, Selenium, P5P
16:00 TMG (1 gram)
23:00 Alpha GPC
NO Vitamin A / Gluten / Glutamate
NO P450 Inhibitors
-Eating oats for Manganese (100 grams about 300% RDA if i am not mistaken). Manganese levels should be checked : Too low or too High is not good.
Since you will start eliminating Supplements, perhaps you could try slowly moving to this subset and evaluate how you feel.
I was hypothyroid for years and was receiving HCG shots for many months since -my hypothesis- the HPTA Axis was affected. I also began having signs of Insulin Resistance.
All is gone now, my endo was amazed..i also think she got a bit upset because i remember her saying to me "Let's see if this lasts, i highly doubt it".
That was 6 months ago. Poor doc...
Notice how Liver_disease, iron_deficiency, Cannabis are on the top levels. Oxidative phosphorylation, PDHC (Pyruvate Dehydrogenase Complex) and notice the entries related to CoA (Coenzyme A)
ABCB2/TAP1 and ABCB3/TAP2 are half-transporters, and form heterodimers in order to function as peptide transporters involved in the MHC-I-dependent antigen presentation. They are localized in the membrane of endoplasmic reticulum, and pump degraded cytoplasmic peptides into the ER lumen where the MHC class I molecular complexes assemble (21).ABCB4/MDR3 and ABCB11/BSEP are involved in the transport of phosphatidylcholine (ABCB4) and bile salts (ABCB11), respectively, across the hepatocyte canalicular membrane into bile.Their mutations are responsible for various forms of progressive familial intrahepatic cholestasis (PFIC); mutations in ABCB4 were found in patients with PFIC3, resulting from a defective transport of phosphatidylcholine across the canalicular membrane (22-24). Mutations in ABCB11 cause PFIC2, in this case the biliary bile salt secretion is very low (25).ABCB6-8 are not well characterized as yet. These are ABC half-transporters, most probably localized in the mitochondrial inner membrane. They likely play a role in the mitochondrial metal homeostasis; ABCB6 probably mediates the transport of an iron complex, ABCB7 and ABCB8 are thought to be involved in the heme transport from mitochondria to the cytosol. They are also candidate genes for inherited metabolic disorders, ABCB6 for the lethal metabolic syndrome, ABCB7 for X-linked sideroblastic anemia with ataxia. ABCB9 is expressed in the lysosomes with unknown function as yet (26).