pattismith
Senior Member
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The Innate Immune System and Inflammatory Priming:
Potential Mechanistic Factors in Mood Disorders and Gulf War Illness
.....Disruption of the innate immune system and inflammation has been correlated with GWI (7). Veterans presenting with the disease show alterations in brain structures and in the integrity of the blood-brain barrier mediated by the immune system. Indeed, brain function in GWI is identical to that found in other immune-related conditions (8) and consequently, GWI has been proposed to be studied as a neuroimmune disease (9). GWI animal models have validated the involvement of neuroinflammatory mechanisms in the pathology of the disease (10), including the over-reactivity of astrocytes and microglia. This increased activation of immune cells was also directly observed in the brain of veterans with GWI (11), while inflammatory biomarkers such as elevated levels of pro-inflammatory cytokines, IL-1β, INF-γ, or IL-6 (12, 13) have been found in the serum of GWI patients. Increased concentrations of inflammatory cytokines are also associated with different mood disorders, including bipolar and major depressive disorders (14, 15). Dysfunction of the innate immune system might be behind the depressive behavior observed in veterans with GWI.....
FULL TEXT AVAILABLE
Potential Mechanistic Factors in Mood Disorders and Gulf War Illness
.....Disruption of the innate immune system and inflammation has been correlated with GWI (7). Veterans presenting with the disease show alterations in brain structures and in the integrity of the blood-brain barrier mediated by the immune system. Indeed, brain function in GWI is identical to that found in other immune-related conditions (8) and consequently, GWI has been proposed to be studied as a neuroimmune disease (9). GWI animal models have validated the involvement of neuroinflammatory mechanisms in the pathology of the disease (10), including the over-reactivity of astrocytes and microglia. This increased activation of immune cells was also directly observed in the brain of veterans with GWI (11), while inflammatory biomarkers such as elevated levels of pro-inflammatory cytokines, IL-1β, INF-γ, or IL-6 (12, 13) have been found in the serum of GWI patients. Increased concentrations of inflammatory cytokines are also associated with different mood disorders, including bipolar and major depressive disorders (14, 15). Dysfunction of the innate immune system might be behind the depressive behavior observed in veterans with GWI.....
FULL TEXT AVAILABLE