Ultra Low Dose Naltrexone plus opioid for better pain relief

PatJ

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This article explains how Ultra Low Dose Naltrexone (ULDN) can be used with opioids to improve the pain relief effect provided by the opioids and avoid the increase in pain that is usually associated with long term use.

"Ultra-low-dose naltrexone seems to help block the activation of glial cells caused by long term opioid use, and prevent the amplification of pain that can be induced by long-term opiate use. At very low doses it can do this without blocking the pain-relieving actions of the opiates. The key is finding the dosage sweet spot where LDN is able to calm the glial cells, but not knock the opiates off their receptors. That sweet spot seems to be around 0.5–1mg, called ultra-low-dose naltrexone (usual low-dose naltrexone is 3–4.5mg)."

For those who deal with pain this might be a useful treatment to look into.
 
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TrixieStix

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This article explains how Ultra Low Dose Naltrexone (ULDN) can be used with opiods to improve the pain relief effect provided by the opiods and avoid the increase in pain that is usually associated with long term use.

"Ultra-low-dose naltrexone seems to help block the activation of glial cells caused by long term opioid use, and prevent the amplification of pain that can be induced by long-term opiate use. At very low doses it can do this without blocking the pain-relieving actions of the opiates. The key is finding the dosage sweet spot where LDN is able to calm the glial cells, but not knock the opiates off their receptors. That sweet spot seems to be around 0.5–1mg, called ultra-low-dose naltrexone (usual low-dose naltrexone is 3–4.5mg)."

For those who deal with pain this might be a useful treatment to look into.
I take opiates and my ME/CFS specialist had me try ULDN (ppl on opiates can only do ULDN) but unfortunately I had a bad reaction to it just hours after my very first dose. Was such a bummer.
 

PatJ

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ppl on opiates can only do ULDN
It's possible to use regular Low Dose Naltrexone even when taking opiates. LDNScience.org has this to say about it:
How soon after taking LDN can I use opiate and opiate-like painkillers?
LDN is metabolized by the body within a few hours (meaning that the body has processed it and gotten rid of it) so after that time is no longer as “available” to interact with other substances. Therefore, as long as LDN and an opiate or opiate-like painkiller are kept apart (staggered) by at least several hours, LDN should not interfere with the pain-relieving effects of the opiate-based medication. However, each person’s metabolism is different, so the assessment of how long to wait after taking LDN should be done in consultation with a physician knowledgeable in LDN and one’s personal medical condition.