Treatment of pain in fibromyalgia patients with testosterone gel

[pattismith]

2015

Treatment of pain in fibromyalgia patients with testosterone gel:

Pharmacokinetics and clinical response

(free full article)
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Testosterone therapy significantly reduces pain in fibromyalgia.

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Testosterone therapy dampens nociceptive neuronal signaling.

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Testosterone serum levels are consistent with beneficial safety/efficacy profile.



Abstract
To test our hypothesis that testosterone deficiency plays an important role in chronic pain, a Phase I/II pilot study was initiated with 12 fibromyalgia patients to verify that a daily dose for 28 days with transdermal testosterone gel would 1) significantly and safely increase mean serum testosterone concentrations from low baseline levels to mid/high-normal levels, and 2) effectively treat the pain and fatigue symptoms of fibromyalgia. Pharmacokinetic data confirmed that serum free testosterone concentrations were raised significantly above baseline levels, by assessment of maximum hormone concentration (Cmax) and area under the curve (AUC) parameters: free testosterone Cmax was significantly raised from a mean of 2.64 pg/mL to 3.91 pg/mL (p < 0.05), and 24 hour free testosterone AUC was significantly raised from a mean of 35.0 pg-hr/mL to 53.89 pg-hr/mL. Assessment of the typical symptoms of fibromyalgia by patient questionnaire and tender point exam demonstrated significant change in: decreased muscle pain, stiffness, and fatigue, and increased libido during study treatment. These results are consistent with the hypothesized ability of testosterone to relieve the symptoms of fibromyalgia. Symptoms not tightly related to fibromyalgia were not improved.

 

[pattismith]

2018

Daily Fluctuations of Progesterone and Testosterone Are Associated With Fibromyalgia Pain Severity



Highlights


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Relationships between sex hormones and fibromyalgia were assessed daily.

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Progesterone as well as testosterone were associated with lower self-reported pain.

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Estradiol fluctuations were not correlated with self-reported pain.

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Pain was particularly elevated when progesterone was low and cortisol was high.



Abstract
The purpose of this longitudinal blood sampling study was to examine relationships between sex hormones and fibromyalgia pain. Eight women meeting case definition criteria for fibromyalgia provided venous blood samples and reported their fibromyalgia pain severity over 25 consecutive days. All women exhibited normal menstrual cycles and were not taking oral contraceptives. Cortisol, and the sex hormones estradiol, progesterone, and testosterone, were assayed from serum. A linear mixed model was used to determine if fluctuations of sex hormones were associated with changes in pain severity.

In the entire sample, day to day changes in progesterone (P = .002) as well as testosterone (P = .015) were significantly and inversely correlated with pain severity.

There was no relationship between estradiol and pain (P = .551) or cortisol and pain (P = .633).
These results suggest that progesterone and testosterone play a protective role in fibromyalgia pain severity. Sex and other hormones may serve to increase as well as decrease fibromyalgia pain severity.

 

[Archie]

Magnesium malate is known to be good for fibromyalgia


https://www.prohealth.com/library/magnesium-malic-acid-one-two-punch-for-pain-fatigue-28914


Well it turns out, that magnesium seems to be the nutrient that boost testosterone in case of magnesium defiency,

https://alphawolfnutrition.com/magnesium-testosterone/


This is the only magnesium product that i can take 1000mg /day with no stomach issues ( 4 in morning / 4 in night ) , and it has also almost 3000mg malic acid with 8 /day dosage .

https://www.jigsawhealth.com/supplements/magnesium/

Vitamin D also might help

 

[pattismith]

I forgot to add that the second study is by Jarred Younger;

Cort Johnson has written several articles about the importance of hormons and testosterone in FM and CFS/ME and about the two articles I have quoted, it's interesting to read the patients comments that say taking testosterone has helped them:


https://www.healthrising.org/blog/2015/06/12/testosterone-connection-fibromyalgia/

https://www.healthrising.org/blog/2018/05/11/sex-hormones-and-fibromyalgia-the-pain-connection/

http://simmaronresearch.com/2018/03/chronic-fatigue-syndrome-fibromyalgia-multiple-sclerosis/