Cognitive decline! yikes! Does frequent serotonin syndrome cause cognitive decline? what's the cause?
I really can not say, but tramadol is know to reduce seizure threshold, who knows what the mechanism is or if it is related. Just after several years of using it, it became more and more obvious that after daily use my memory and ability to recall information became horrendous. Tramadol is a unique opiate I believe, not the same as most standard ones, seems to have some odd sides and activity.
I do not want to put anyone off from using it, I found it incredibly important and helpful for sometime, you just need to keep an eye on it, same with any pain meds I imagine.
On the serotonin syndrome, you just need to be careful of any supplements or meds that will also activate serotonin I guess.