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To treat some diseases, researchers are putting immune cells on a diet

Gondwanaland

Senior Member
Messages
5,092
Anyone to break down the info please?
http://www.sciencemag.org/news/2018/03/treat-some-diseases-researchers-are-putting-immune-cells-diet
To treat some diseases, researchers are putting immune cells on a diet
...
Alternative energy sources
Activated immune cells change what they consume and which metabolic pathway they use to break down that fuel to produce energy-carrying ATP. Some types load up on glucose, increasing glycolysis, and they consume more glutamine. Fatty acids remain a staple for other cells, which still depend on oxidative phosphorylation.

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nanonug

Senior Member
Messages
1,709
Location
Virginia, USA
Anyone to break down the info please?

It's a messy article, short on details. The main message is that of tinkering with immunity by changing metabolic pathways in immune cells. Some of these ideas are not so new. For example, the use of dichloroacetate in cancer as a way to deal with the Warburg effect is hardly "news." I am utterly unimpressed.