Any special tips you can share?
Economy comfort or similar is a cheap upgrade which can be extremely helpful. If you're behind the bulkhead in the center, there's plenty of room to prop your feet up on your carry-on, or just wedge your feet against the wall.
If the closest toilet is at the back of first class, let a flight attendant know that you're disabled and can't walk far and ask if it's okay to use the first class toilet during the flight. They'll ask the flight attendant boss, but I've never been turned down. Best time to ask is during the disabled pre-boarding.
Make sure you wait for them to bring a wheelchair, and that you get pushed up to the door of the airplane. The jerks at the Amsterdam airport put me on a cart once, which meant I was dumped at the gate. So it ended up being too much walking and standing, though the gate security guy did see me looking ready to cry while I was standing in line, and got me through faster.
You're supposed to wait until everyone disembarks before shuffling off the plane, but I've had my reserved wheelchair disappear that way before. So get off as soon as you know you won't have to be standing too long before getting to the door.
Try to keep one leg up as much as possible. My heart rate monitor shows that it helps a lot, and it can be done while in a wheelchair or even in your airplane seat by propping one leg up on the other thigh.
Be extra conscientious about avoiding all exertion. It's easy to think that we should be doing a little bit to make things easier for security, etc, but it really adds up when traveling. It's a time to compromise less on pacing, not more.