athene, what's the difference between Fructose Malabsorption and Leaky Gut Syndrome? Is it just a form of LGS? Anyway I ordered the two supplements you mentioned and will give them a shot!
Hiya!
Good luck with these, I hope they help you too!
Normally fructose is moved into the blood by a transport factor called GLUT-5, which is produced and secreted by cells lining the intestine and attaches to the molecules of fructose, allowing them to cross into the blood stream. Fructose malabsorption means thee cells are damaged. You cannot absorb fructose (or only a tiny amount) from the gut into the bloodstream. This means it stays in the gut and is fermented into gases (usually hydrogen) by gut bacteria, and osmotically draws water into the gut. In terms of symptoms this means you get farts, diarrhoea and lots of pain.
Leaky gut comes from a problem with the way the cells lining the intestine are stuck together. They are supposed to be firmly attached to one another (like bricks in a wall cemented together) and nearly all types of nutrient molecules are only allowed between them if attached to transport factors, of which GLUT 5 would be one example. In leaky gut the cement is damaged so you have something like a drystone wall, which lots of naughty molecules can slip through and enter the blood stream.
The big questions here are, what hold the cells together, and why has it become leaky?
Apparently one of the things that holds them together is sulphation, which involves a coating including sulphur, so people who (like me) have lost the ability to convert sulphites into sulphates have a problem here.
I think these supplements have a role to play too as they heal the cells, which may mean they improve their ability to reinforce the "wall".
One reason (I am starting to think) that they become leaky in the first place is biofilms inthe gut. The biofilms cling to the surface of these cells and dig in, so that there are bacteria actually wedged between some of the cells of what should be an imprenetrable barrier.
There's a diagram of them on this page.
http://www.autismpedia.org/wiki/index.php?title=Usman
(scroll down to "intact mucosal barier and disturbed mucosal barrier", which shows a picture of cells lining a leaky gut)
I am still not sure how much these sups have repaired my leaky gut. So far, what I think is, improved but not totally resolved. But I am only able to go on what symptoms I usually get from dairy and gluten (mainly) and try to unravel them from all the other symptoms I get anyway, which is not easy. Lots of different things can give me a headache, for example.
I am waiting on tenterhooks for Globalpilot to do the leaky gut test so we can get an actual measurement!
I cannot find any lab/doctor where I live which does this test.
Athene