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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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I always find that if I reiterate it to myself and others that it sticks alot better. We remember 15% of what we read but 90% of what we teach, kinda thing.
So as per Dr. Kerr and others gene studies we know that this specific gene is turned off in ME patients. Sense we had normal function before we began express ME symptoms then this is a case of epigenetics turn this particular gene off.
T,B and NK cells are all part of the white blood cells that function as our immune system. Once this gene is turned off then we can no longer replenish our NK or natural killer cells as fast as normal. Mother nature in her infinite wisdom however provides back up systems to keep us going in the event of a Retroviral attack. So the T cells now kick in to pick up what the NK cells, can no longer do, due to low numbers.
The secondary system of T1 and T2 however have the problem of creating a chemical imbalance that effects the HPA system, in effect dis-regulating the hormones that regulate many of the bodies other functions via signals from the pituitary gland et al. So we get gut problems and problems with pancreatic function and other glands.
So the bugs come in but they don't get out. Hence the frequent sore throats and swollen lymph glands that are criteria for ME. The system is on the job 24/7 without a rest. That could explain the constant fatigue. Plus dysregulation of the hormones for creating energy.
True that Rich is a very smart man but you got the lid off of the peanut butter jar for me!
This "never sick with colds or flu" is very common in autism too. Many kids are never sick, and a small minority are sick all the time.
I was wondering if this could also be down to "superinfection exclusion", at least in some cases - where one pathogen takes up residence and no other virus is able to enter the cell. This is well known to happen, but (my) one big issue with this theory is that the supposed original pathogen (say xmrv) would in that case have to be residing in all tissue that common cold and flu viruses would normally go for: lung, sinuses etc.
Is something like this a plausible scenario? Any thoughts Gerwyn or anyone?
Mistress Kim (who shall be worshiped - by me, anyway),
Would it be possible to move this particular part of the discussion to its own thread? I am so happy to see this particular mystery discussed in such an intelligent way and would hate for any to miss it!
Many thanks either way,