The immune paradox of SARS‐CoV‐2: Lymphocytopenia and autoimmunity evoking features in COVID‐19 and possible treatment modalities

[SWAlexander]

Abstract
SARS‐CoV‐2 causes multiorgan damage to vital organs and tissue that are known to
be due to a combination of tissue tropisms and cytokine‐mediated damage that it
can incite in COVID‐19. The effects of SARS‐Co‐2 on the lymphocytes and there-
fore on the immune response have attracted attention recently in COVID‐19 to
understand its effects in causing a chronic state of ongoing infection with Long‐
COVID. The associated lymphopaenia and autoimmune disease state, which is an
apparent paradox, needs to be researched to dissect possible mechanisms under-
lying this state. This paper attempts to unravel the aforesaid immune paradox ef-
fects of SARS‐CoV‐2 on the lymphocytes and discusses appropriate treatment
modalities with antiviral drugs and nutraceuticals which could prove virucidal in
SARS‐CoV‐2 seeding monocytes and lymphocytes in patients with COVID‐19 and
Long‐COVID. Importantly it proposes a new in vitro treatment modality of immune
regulating cells that can help patients fight the lymphopaenia associated with
COVID‐19 and Long‐COVID

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