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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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The First Biomarker-Driven Treatment Trial for ME/CFS

SWAlexander

SWAlexander

Senior Member
Messages
2,018

Subsets Mean Success​

Until now, the heterogeneity of the patient population and the lack of a reliable biomarker to diagnose and prognose ME/CFS has thwarted clinical trials for both non-approved FDA drugs as well as repurposed agents.
We have recently identified elevated levels of inactive ATG-13 as a testable and targetable pathway for treating symptoms of post-exertional malaise.

Biomarker to Treatment Trial​

Rapamycin therapy inhibits mTOR and reduces autophagy disruption. We believe that a subset of patients may have chronic mTOR activation that can lead to the symptoms of ME/CFS. By taking rapamycin, the mTOR inhibitor, we hope that these people may see a significant reduction in symptoms.
We will track symptoms and autophagy markers in this study.
https://www.simmaronresearch.com/rapamycin-trial

What is: Chronic activation of the mTOR pathway has significant implications for cellular and organismal health
Short introduction: https://swaresearch.blogspot.com/2023/11/chronic-activation-of-mtor-pathway-has.html
 
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