http://www.heartfixer.com/AMRI-Nutrigenomics.htm
Sulfite is neurotoxic. Sulfite will be over produced by the CBS up regulation, and then requires conversion in to the less toxic sulfate molecule by the enzyme Sulfite Oxidase (SUOX). SUOX can easily be overwhelmed. Molybdenum is required for SUOX function, and is typically depleted in CBS (+/+) or (+/-) individuals. Molybdenum supplementation (3 drops or 75 mcg of e-lyte Molybdenum twice a day), Boron 3 mg/day, Vitamin E succinate 400 IU/day, and hydroxy-B12 2000 mcg/day are also utilized to speed up SUOX activity.
While
sulfate is less toxic than is sulfite, it will stimulate the adrenergic (fight or flight) limb of the autonomic nervous system and stimulate a cortisol stress response, revving you up into an unrelenting biochemical overdrive. If you have a CBS defect, we need to restrict your sulfur intake, at least until your urine sulfate (and your body sulfate burden) has decreased. The amino acids methionine, taurine, and cysteine all contain sulfur; they are concentrated in animal protein (thus the restriction on animal protein intake). Many nutritional supplements (MSM, N-acetyl cysteine, glutathione) that are good for most people are a problem for you. While certain aspects of your health will benefit from these agents, they will add to your sulfate/sulfite overload problem, adversely affecting the Methyl Cycle Defect that is the common denominator to all of your health problems
---
idk about all this sh*t above. I have a CBS +/+ and a CBS +/- and yet I have HIGH molybdenum.
I require high DHEA or else I get panic attacks (due to cortisol higher than the proper DHEA:cortisol level which governs how much stress one can take). However during allergy season (50% of my life) I am low cortisol and I need DHEA to be able to make cortisol...my adrenal gland craps out from insufficient zinc leading to insufficient thyroxine, etc). So I don't know what to say about cortisol since mine is all over teh map depending on whatever else is going on.
It seems to me that the one to worry about is SULFITE as it is the one that is toxic. If you have no SUOX defect and no molybdenum shortage, your body will turn it into SULFATE, whose only problem is raising cortisol. Ok, maybe that is a problem if you don't have enough testosterone (via DHEA) to regulate CBS, but that is how I regulate my CBS. I guess it could be interesting to test.
I don't guess I have any SULFITE problem due to none of the issues that would block its conversion to SULFATE so the only useful thing would be to test SULFATE. Actually it would be interesting if they sold ONE sulfite test strip with the sulfate test strips just to be sure about the sulfite.