Tenofovir, is it similar to cmx001?

[heapsreal]

Im looking up alternative treatments for cmv and i know some antiretro's have a broader spectrum of effect, they may be active against herpes viruses as well as enteroviruses.

Researching tenofovir for cmv, cmx001, the drug Dr Peterson was interested in, that is a new improved version of cidofovir, suppose to have a broad effect on viruses with good effect on ebv/cmv/hhv6. SO anyway looking up tenofovir, i also keep seeing alot mentioned about cmx001, tenofovir is referred to as cmx157.

I would like to know if anyone can tell me if they have a similar effect.

Page 3 of this link https://www.blsmeetings.net/2009GHSImeetingsMCM/presentations/Bio/Painter-Chimerix-Smallpox-MOD.pdf makes it appear they may be closely related. This link doesnt have alot of info on tenofovir, mostly cmx001.

If tenofovir is more effective than standard avs for cmv thats great, another plus is that it seems to be more cost effective, requires 1 dose a day and a much longer half life than regular antivirals, so would think be better at suppressing viruses????????

cheers!!

 

[acer2000]

I'm fairly certain that Tenofovir is traditionally used as an anti-retroviral drug. Although I think it is sometimes used for other RNA viruses like Hep-B.

 

[Jammy88]

I'm fairly certain that Tenofovir is traditionally used as an anti-retroviral drug. Although I think it is sometimes used for other RNA viruses like Hep-B.

@acer2000 is right. Tenofovir (commercial name: Truvada) is a widely used ARV's for treating HIV. At the same time, it is the only drug which can manage HepB infection. Moreover, it is active against HTLV - and, I' d say, possibly, other unknown retroviruses.

 

[heapsreal]

@acer2000 is right. Tenofovir (commercial name: Truvada) is a widely used ARV's for treating HIV. At the same time, it is the only drug which can manage HepB infection. Moreover, it is active against HTLV - and, I' d say, possibly, other unknown retroviruses.

Yes its just hard to find more information on what effects other antivirals may have other than the initial indications of the medications used to bring the drug to market.

I think many antivirals/retro's have a broader range of action than we realise or are told. Famvir has activity against HepB also and it seems from Dr Chia's work that some Hep antivirals have activity against enteroviruses.

Isentress is suppose to have direct activity against herpes viruses but its still quite an expensive drug.

And yes potential unknown retroviruses.
If a drug has activity on multiple viruses than its like having an each way bet.

 

[Jammy88]

Yes its just hard to find more information on what effects other antivirals may have other than the initial indications of the medications used to bring the drug to market.

I think many antivirals/retro's have a broader range of action than we realise or are told. Famvir has activity against HepB also and it seems from Dr Chia's work that some Hep antivirals have activity against enteroviruses.

Isentress is suppose to have direct activity against herpes viruses but its still quite an expensive drug.

And yes potential unknown retroviruses.
If a drug has activity on multiple viruses than its like having an each way bet.

I'm definitely interested in this topic, as I am myself dealing with an unknown (retro?)virus and there's no way to get diagnosis/treatment… God knows how much I'd want to try ARV's. The problem is that here in Italy nobody would ever give me a prescription for such a drug - being of course Hiv neg.

:-(

 

[acer2000]

Yeah the issue with drugs approved as ARVs being used off label is weird. As far as medications go, they have some of the best understood safety profiles of anything on the market. Heaps of money has gone into their research and there are millions of people taking them everyday for years at a time so there has been a lot of "real world" experience beyond what the FDA did. Yet doctors are very hesitant to test them in conditions other than HIV.

 

[heapsreal]

Yeah the issue with drugs approved as ARVs being used off label is weird. As far as medications go, they have some of the best understood safety profiles of anything on the market. Heaps of money has gone into their research and there are millions of people taking them everyday for years at a time so there has been a lot of "real world" experience beyond what the FDA did. Yet doctors are very hesitant to test them in conditions other than HIV.

Also once a drug has come to market, they no longer do alot of research on it to see if its effective for other illnesses.Also with a limited indications of use, it then becomes harder to get approved for off label use and covered by insurance companies and health systems unless payed for unsubsidised .

 

[diwlo]

Hi. Obviously, I completely understand that you are looking for adequate treatments for your CMV, but I can only advise you not to take Truvada if you are not hiv+. My chronic fatigue syndrome started after a four-week course of Truvada/Kaletra I had to take as a post-exposure prophylaxis. My life has been hell ever since. There is only very little research on the effects of ARVs on a hiv- organism. So don't take that stuff.

Here is my initial post:
http://forums.phoenixrising.me/index.php?threads/hello-from-belgium.33399/#post-517605

And a recent paper on ARVs causing some other disorder:
http://www.biomedcentral.com/1471-2474/15/265

 

[heapsreal]

Hi. Obviously, I completely understand that you are looking for adequate treatments for your CMV, but I can only advise you not to take Truvada if you are not hiv+. My chronic fatigue syndrome started after a four-week course of Truvada/Kaletra I had to take as a post-exposure prophylaxis. My life has been hell ever since. There is only very little research on the effects of ARVs on a hiv- organism. So don't take that stuff.

Here is my initial post:
http://forums.phoenixrising.me/index.php?threads/hello-from-belgium.33399/#post-517605

And a recent paper on ARVs causing some other disorder:
http://www.biomedcentral.com/1471-2474/15/265

I understand but how sure are you that it was the arvs and not some other bug you may have picked up?
I have been in contact with a couple of cfs people who have improved quite alot on tenofovir, they also fit ebv/cmv/hhv6 sub groups.

My understanding is that tenofovir is much cheaper and alot easier to tolerate than valcyte which is indicated for cmv.
Im just looking for other option to treat ebv/cmv.

 

[diwlo]

I just felt that I had to share my experience with you and that this would help you decide what option you should choose. It's good to make decisions in an informed way, I think. But as you say, we don't really know why most of us are just permanently exhausted and we are all desperately looking for explanations and treatment. If ARVs help you, fine, but they might also make things worse. Take care.

 

[heapsreal]

I just felt that I had to share my experience with you and that this would help you decide what option you should choose. It's good to make decisions in an informed way, I think. But as you say, we don't really know why most of us are just permanently exhausted and we are all desperately looking for explanations and treatment. If ARVs help you, fine, but they might also make things worse. Take care.

Thanks for your reply. I appreciate it.

Its hard to weigh up the risk vs value with many treatments not approved for cfs/me.
Its good to hear personal experiences as we dont hear alot about them just statistics, as well as not really hearing about severity of possible adverse effects.

 

[Iquitos]

http://forums.phoenixrising.me/inde...inked-to-neurodegeneration.36318/#post-574316
And this thread has info on the alleged damage to mitochondria of Truvada and other arvs.

 

[heapsreal]

http://forums.phoenixrising.me/inde...inked-to-neurodegeneration.36318/#post-574316
And this thread has info on the alleged damage to mitochondria of Truvada and other arvs.

Do you have the correct link as the thread u mention as nothing about truvada or other arvs causing mito damage.

 

[Iquitos]

Sorry, I must have read it elsewhere. I'll see if I can find it again.

 

[Iquitos]

@heapsreal http://www.ema.europa.eu/ema/index....4/human_med_001113.jsp&mid=WC0b01ac058001d124
(of risks it says "....mitochondrial dysfunction (damage to the energy-producing components within cells than can cause problems in the blood).)

 

[PhoenixBurger]

Well I guess I am in a unique position to reply to this thread. But @heapsreal I think you already know my story. I got into this mess in the first place by taking HIV anti-retrovirals. Therefore for what its worth, I would absolutely advise you to stay as far away as possible from them. Mitochondrial damage, neuropathy, generalized DNA damage, blood disorders - all common with these medications. I wouldn't touch them with a 10 foot pole.

IRIS is the least of your possible worries. Some tolerate it fine. I know of at least 10 other people who ended up with years of problems from a 30 day course. Major system-wide problems with no explanation to date. I even personally made a website dedicated to the topic called PEP Side Effects.com (currently taken down) ... and the stories were all the same.

http://aras.ab.ca/haart-mitochondria.php

http://www.natap.org/2010/HIV/062010_01.htm

http://www.drugs.com/disease-intera...esspak-for-hiv-pep-expanded-with-kaletra.html

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC442998/
http://www.aidsmap.com/Causes-of-mitochondrial-toxicity/page/1730373/
http://aras.ab.ca/azt-cancer.php

 

[cornwellsb]

I actually was recently diagnosed with cfs after 5 or 6 years. I started taking truvada as a HIV prevention about 1 year ago without realizing I had cfs. I noticed my symptoms of cfs started drastically getting better after about 6 months ... I just put it all together and really think it helped. I still had fatigue and other issues and after seeing a specialist I discovered it was cfs. I added valtrex and valcyte into to mix. Long story short I believe the truvada was really helping and now the other AVs have really pushed me to almost full recovery. I actually think I got the most benefit from valtrex. I am on valcyte but I am not sure if it is even helping. I just posted my thoughts in a separate thread about good results from valtrex and valcyte but as mentioned in the thread, my life became much better after truvada.