Hi zz0r,
One can have a lot of food sensitivities, MCD, hypersensitive to odors, textures, just about anything, when folate deficiency symptoms are heavy, as with methyltrap. Gluten can make a huge difference if you are gluten sensitive, or dairy. However, if you are like me you won't be able to tell until the deficiency symptom food sensitivities go away and see what remains. If you have celiac disease gluten can make you quite ill. It wasn't until I did an elimination diet after being on MeCbl and AdoCbl for several years and at least400mcg Metafolin that the elimination diet made any difference. I can't eat cheese, milk, whey but I can have cream and a little butter.
The potassium might start on the third day after starting AdoCbl,, MeCbl and Metafolin. This will usually start up methylation and rapid cell formation from long pent up demand. That causes low potassium frequently. If startup doesn't happen then add in L-carnitine fumarate. That limits startup to about half the levels of healing at first. That is usually more than enough to deal with at first.
There is a lot of reading to do. It is like solving a giant maze. You get clues in the form of changing symptoms, new symptoms, strengthening of neurological symptoms and all these allow you to follow the clues of healing. The low potassium and low folate symptoms are usually the first clues and then one deals with these induced deficiencies and moves on to the next thing.
Typically several of these symptoms will appear suddenly with more appearing and worsening over time if corrections are not made. While these groups of symptoms are called “detox” by some alternative practitioners and many people otherwise knowledgeable about vitamins and supplements, depending upon what theories they are operating under, use this term. Typically they are working on a “toxin” theory of CFS/FMS/ME/MCS etc and that these vitamins and supplements mobilize the toxins which then cause all sorts of symptoms in the groups listed. As the “translations” are made it is clear that actual “detox” if it exists, has nothing to do with these symptoms and they can be dangerous to ignore. If it is “detox” in an actual sense, then it is in what is left after these other things are accounted for and/or corrected, perhaps 5-10% of the total initial number. Also, co-morbidities often show up in this way..
Group 1 – Hypokalemia onset. Symptoms may appear with serum potassium as high as 4.3. May become dangerous if ignored. Considered “rare” with cyanocobalamin it is very common with methylb12 and adensosylb12 and less so with hydroxycobalamin..
IBS – Steady constipation , Nausea, Vomiting, Paralyzed Ileum, Hard knots of muscle, Sudden muscle spasms when relaxed, Sudden muscle spasms when stretching , Sudden muscle spasms when kneeling, Sudden muscle spasms when reaching , Sudden muscle spasms when turning upper body to side, Tightening of muscles, spasms and excruciating pain in neck muscles, waking up screaming in pain from muscle spasms in legs. Muscle weakness, Abnormal heart rhythms (dysrhythmias), Increased pulse rate, Increased blood pressure, Emotional changes and/or instability, dermal or sub-dermal Itching, and if not treated potentially paralysis and death.
Group 2a - Both
IBS – Diarrhea alternating with constipation, IBS – Normal alternating with constipation
Group 2b – Either or both
Headache, Increased malaise, Fatigue
Group 3 - Induced and/or Paradoxical Folate deficiency or insufficiency
IBS – Steady diarrhea, IBS – Diarrhea alternating with normal, Stomach ache, Uneasy digestive tract, increased hypersensitive responses , Skin rashes, Increased acne, Skin peeling around fingernails, Skin cracking and peeling at fingertips, Angular Cheilitis, Canker sores, Coated tongue, Runny nose, Increased allergies, Increased Multiple Chemical Sensitivities, Increased asthma, rapidly increasing Generalized inflammation in body, Increased Inflammation pain in muscles, Increased Inflammation pain in joints, Achy muscles, Flu like symptoms, Depression, Less sociable, Impaired planning and logic, Brain fog, Low energy, Light headedness, Sluggishness, Forgetfulness, Confusion, Difficulty walking, Behavioral disorders, Dementia, Reduced sense of taste, Increase irritability, Loss of reflexes, Fevers, Old symptoms returning, Heart palpitations, Bleeding easily.
Group 4 - Hydroxycbl onset, degraded methylcbl onset, methylcbl after photolytic breakdown onset.
Itchy bumps generally on scalp or face that develops to acne like lesions in a few days from start.
Group 3 symptoms, induced paradoxical folate deficiency or insufficiency are corrected quickly with titrated doses of Metafolin, methylb12 and adenosylb12. If glutathione (precursors) are the cause then larger doses of Metafolin, 7.5-15mg,or maybe more are needed. Different tissues are affected at different levels of methylfolate, it comes or goes in stages. Very strong dose proportionate characteristics are present. Serum folate levels may be high or even very high despite Metafolin responsive deficiency/insufficiency symptoms.
Group 1 symptoms respond readily to potassium. The symptoms and response to potassium may occur at a serum level of 4.3 or less.