@Forçe e Honra, thanks for asking. These are the ones I've had:
-ANA screen, IFA
-DNA (DS) antibody
-Sjogren’s antibody (SS-A)
-Sjogren’s antibody (SS-B)
-SM Antibody
-SN/RMP Antibody
-SCL-70 Antibody
Is there another kind that I missed?
Also can the values change over time, do you know? Where I would be negative one time on the test but possibly positive if tested again?
Yes, values can change over time and in fact with SS, many people are negative for all those for many years before getting a positive.
The Early SS Screen tests for different antibodies which are tools for catching SS early, vs. the average of 3 years from onset of symptoms (though I've also read other stats that list 5 years):
Q. Is it easy to diagnose Sjögren’s?A. Sjögren’s often is undiagnosed or misdiagnosed. The symptoms of Sjögren’s may mimic those of menopause, drug side effects, allergies, or medical conditions such as lupus, rheumatoid arthritis, fibromyalgia, chronic fatigue syndrome, and multiple sclerosis. Because all symptoms are not always present at the same time and because Sjögren’s can involve several body systems, physicians, eye care providers and dentists sometimes treat each symptom individually and do not recognize that a systemic disease is present.
The average time from onset of symptoms to diagnosis is 3 years.
https://www.sjogrens.org/home/about-sjogrens/sjoegrens-faqs
From
Quest Diagnostics:
https://www.questdiagnostics.com/testcenter/BUOrderInfo.action?tc=93748&labCode=AMD
The current Ro and La antibodies can delay the diagnosis by over 6 years. Recently novel antibodies identified to
salivary gland protein 1 (SP-1),
carbonic anhydrase 6 (CA6) and
parotid secretory protein (PSP) using western blot methodology. Further studies have shown that the isotype differentiation of the markers adds to the sensitivity of diagnosis of SS. These autoantibodies occurred earlier in the course of the disease than antibodies to Ro or La. In addition antibodies to
SP-1, CA-6 and PSP were found in patients meeting the criteria for SS who lacked antibodies to Ro or La. Furthermore, in patients with idiopathic xerostomia and xerophthalmia for less than 2 years, 76% had antibodies to SP-1 and/or CA6 while only 31% had antibodies to Ro or La.
Antibodies to different isotypes (IgG, IgM & IgA of SP-1, CA6 and PSP are useful markers for identifying patients with SS at early stages of the disease or those that lack antibodies to either Ro or La.
I tested positive for 2 of the antibodies first time testing, then positive for another the second time tested (couple months apart). So positive for all 3.
Additionally, I went to the Opthalmologist and got a Schirmer's Test (tear test), which was positive for Dry Eyes. Another symptom of SS. Coincidentally, I also found out I have Blepharitis (in my case inflammation of the eyelids vs. at the lash line), which is found in approximately 70% of those with SS. Using the simple methods the Opthalmologist prescribed has helped tremendously to reduce my eye discomfort*. (
*Washing lash lines and eyebrows 2x daily with Dr. Bronners - they recommend baby shampoo - warm compresses, I bought a microwavable one which I am supposed to do daily but don't always - and my own therapy to apply virgin coconut oil on my damp face, then eyes, that has 3 drops of tea tree oil mixed in at least once a day, often I do 2x a day.
My specialist put me on Plaquenil which will help with so many of the sx of SS (hopefully, only on it 6 weeks and feel a bit stronger, but can take up to 6 months to reach full efficacy) - and these are the sx I have that he stated are associated with SS:
"It is an autoimmune disease very associated with/causing dysautonomia, fatigue, pain."
Which in my case, is quite accurate.
Hope this helps.