Just found this abstract - don't have access to the full version. Don't know if someone else has posted it. The title has been cut off in the thread title but I can't edit it. It may be that a mod would like to alter it to make more sense.
Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors
+ Author Affiliations
- aDivision of Virology, MRC National Institute for Medical Research, London NW7 1AA, United Kingdom; and
- bDepartment of Infectious Diseases, King's College London School of Medicine, Guy's Hospital, London SE1 9RT, United Kingdom
- Edited by Stephen P. Goff, Columbia University College of Physicians and Surgeons, New York, NY, and approved February 2, 2010 (received for review November 25, 2009)
Xenotropic murine leukemia virus-related virus (XMRV) is a recently discovered gammaretrovirus that has been linked to prostate cancer and chronic fatigue syndrome. This virus is therefore an important potential human pathogen and, as such, it is essential to understand its host cell tropism. Intriguingly, infectious virus has been recovered from patient-derived peripheral blood mononuclear cells. These cells express several antiviral restriction factors that are capable of inhibiting the replication of a wide range of retroviruses, including other gamma retroviruses. This raises the possibility that, similar to HIV, XMRV may have acquired resistance to restriction. We therefore investigated the susceptibility of XMRV to a panel of different restriction factors. We found that both human APOBEC3 and tetherin proteins are able to block XMRV replication. Expression of human TRIM5α, however, had no effect on viral infectivity. There was no evidence that XMRV expressed countermeasures to overcome restriction. In addition, the virus was inhibited by factors from nonhuman species, including mouse Apobec3, tetherin, and Fv1 proteins. These results have important implications for predicting the natural target cells for XMRV replication, for relating infection to viral pathogenicity and pathology, and for the design of model systems with which to study XMRV-related diseases.