Jenny TipsforME
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@PennyIA lovely to think a baby has come out of your knowledge
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hetero in MTHFR A1298C
though don't understand VDR relationship with COMT yet
I also have the Warrior gene
Usually the research is showing a very small increase in risk, and does not say if someone will get a disease or not. Some SNPs do cause disease directly, but most SNP research is showing very little effect, and is very vulnerable to false positives.Celiac confused me, a couple of susceptible snps including a main one. Had blood test 16yrs ago which was negative. Does that measure expression rather than dna?
I was curious about what the coeliac blood test I had tested, looked up it'sUsually the research is showing a very small increase in risk, and does not say if someone will get a disease or not. Some SNPs do cause disease directly, but most SNP research is showing very little effect, and is very vulnerable to false positives.
Celiac confused me, a couple of susceptible snps including a main one. Had blood test 16yrs ago which was negative. Does that measure expression rather than dna?
What would your attitude be for conditions you have symptoms for and relevant SNPs? Is this worth raising with a doctor? For example, I noticed a number of autoimmune conditions
- NAT2 slow metaboliser
- CYP2D6*10 reduced Metabolism
- CYP3A5 non expressor
I'm finding the way information is presented in https://www.infino.me/genetics/ helpful. This is free.
This would slow the enzyme very slightly. The Yasko stuff about this SNP affecting the backwards reaction of the enzyme in which a molecule of BH4 is generated, and thus that the SNP compromises BH4, is yet another of her total misreadings of research.
The enzyme does not run backwards and it does not regenerate BH4, though methylfolate does act as a peroxynitrile scavenger so it could have a BH4 sparing effect.
The SNP simply has a small slowing effect on the normal (forward) action of the enzyme. Here is a post about this SNP.
Don't fall for the Yasko stuff that COMT = too much dopamine and hence intolerance of methyl groups and that VDR Taq offsets this somehow since it lowers vit D which in turn stimulates dopamine production.
COMT and intolerance of methyl groups is pure speculation and plenty of people have put it to the test and found it not to be the case.
VDR Taq affects the VDR, not vit D and acutally has been shown to have little effect.
There's a lot of nonsense written about this MAO A SNP, which in itself does nothing at all. Here is a post about it.
Good luck - you are on an interesting journey.
Just interested in why you think yasko is wrong. I have +/+ on both COMTs and MAO-A and have ruined sleep with methylfolate. Do you think my poor sleep is due to some other reason
so from my experience COMT plus MAO A homozygous definitely cause problems of overstimulation