• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To register, simply click the Register button at the top right.

Stress induced epstein barr re-activation [STUDY] 2021


Senior Member
United Kingdom
Have been suffering from this this year, twice so far, second time seemed a lot worse than the first.


But I don't remember seeing this study posted, so thought people might want to discuss.

It describes 4 different types of ebv re-activation. I can only assume tiredness and mild fatigue are stage 1, with chronic igg levels being stage 5, but not sure.

Oxidative Stress/Reactive Oxygen Species and EBV Reactivation
Recent research has examined the role of oxidative stress in EBV reactivation. Chaetocin is an antiproliferative made by Chaetomium fungi that is capable of generating ROS [142]. Real-time RT-PCR revealed that chaetocin treatment upregulated the immediate early genes BZLF1 and BRLF1, the early gene BMRF1, and the late gene BLLF1. This was associated with an increase in the viral copy number. Treatment with the ROS inhibitor N-acetyl-L-cysteine counteracted the effect of chaetocin, indicating that ROS induction is associated with the lytic EBV cycle [143].

This bit really interests me, plenty of other studies have proven OS levels are high, which is why I take R-ALA, NAC, glycine (meant to be anti inflammatory and was recommended by Dr Goldstein) and liposomal glutathione to keep my OS levels down. I guess this must have worked in my case because the terrible swelling I had at the base of my skull disappeared and that was just with NAC and R-ALA

I do think that if certain viruses more aggressively mess up with the immune system or ebv specifically for the purpose of this thread is activated chronically then getting it under control even with antivirals (based on threads I've read on this forum) seems really difficult. Unless of course patient could afford Valcyte, get regular tests, tolerate it and get a doctor to assist.

Anyway the mention of NAC and ROS just really interested me as that was a core piece of Josh's protocol and this study came out after he wrote his herpes study. It's not about who got what right, I am more interested in the fact that a disease vertical keeps appearing, in this case OS (oxidative stress).

OS meta analysis 2020 https://www.sciencedirect.com/scien...howed,greater oxidative stress after exercise.