what's odd is that I couldn't tolerate any high doses of antidepressants over the years, yet for a month now i've been doing 800mg a day of Ral and tolerating it so far. Go figure!
jimbob,
it could be because--
RAL is not metablolized by P450 enzymes,
antidepressants are.
and chronic infections, immune activation & cytokine exposure
dysregulate P450 enzymes.
ThePharmaLetter, October 22, 2007, excerpt:
Merck also reported data from a series of drug interaction studies, which demonstrated that no adjustment in Isentress dosage was required when co-administered with other antivirals.
The firm added that its product is not metabolized by cytochrome P450 enzymes, and therefore has an extended therapeutic half-life.
Gemini