spironolactone vs. cfids (autism) any opinions?

Navid

Senior Member
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**** i read this on another group that discusses xmrv and autism....wondering what people here know and or think about this drug as a potential treatment for cfids.

thanks, lisa


Some Defeat Autism Now doctors have been using spironolactone on autistic
children for years. It is primarily a diuretic drug, but it has strong
anti-inflamatory properties as well, especially on the brain, and it is potent
anti-androgen as well. here is a paper related to spironolactone:

http://www.icdrc.org/documents/Bradstreet Spironolactone Author Copy.pdf


> Link between autism and abnormal blood-vessel function and oxidative stress
>
> http://www.eurekalert.org/pub_releases/2006-08/uops-lba081506.php
>
> Practio discusses a link between autism and abnormal blood-vessel function and
oxidative stress
>
> Quote "Compared with controls, children with autism had significantly higher
urinary levels of isoprostane "[a biomarker for oxidative stress ]
>
> Pratico and colleagues measured levels of isoprostane, the chemical byproduct
of free radicals attacking fat cells and found that patients with autism possess
nearly double the level of oxidative stress than that measured in healthy
controls.
>
> Pratico's team measured isoprostane, a biomarker for oxidative stress;
thromboxane, an index of platelet activation; and prostacyclin, a measure of
blood vessel activation in the samples. "This study represents the first
observation that the rates of thromboxane and prostacyclin synthesis are both
not only significantly increased in autism, but are closely correlated with the
rate of oxidative stress," says Pratico. Compared with controls, children with
autism had significantly higher urinary levels of isoprostane, thromboxone, and
prostacyclin.
>
> In general, it is known that abnormalities in blood vessels can be clinically
reflected by an abnormal blood flow," says Pratico. "In this regard, it is
interesting that earlier neuroimaging studies of autistic children have
demonstrated a reduced amount of blood reaching the brain. Shedding more light
on the relationship of oxidative stress and blood-vessel health to the pathology
of autism could lead to improvements in therapy."
>
 

Tammie

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well, there are definitely similarities between autsim and CFS, but I know that I, and many others with CFS, already have problems with needing to urinate WAY too often, so something that acts as a diuretic could be REALLY bad for us
 
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I have taken low dose spironolactone in the past for PCOS. I now take drosperinone in my birth control pills (Yasmin), it's comparable to 25mg Spiro. I have a LOT of water retention without it. My face, especially, gets very puffy. It definitely controls my PCOS symptoms, which makes me feel better as a whole, but I haven't noticed any effect on my CFIDS symptoms. Well, I think endocrine dysfunction IS a part of CFIDS, so if you look at it that way, I guess it does really help.