someone sent me this article, is it just clickbait ?

slysaint

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Article claims fibromyalgia has been solved ....
http://haleyourself.com/fibromyalgi...earchers-find-main-source-pain-blood-vessels/

couldn't see it talked about here anywhere so it could be old news, thought I would check though as it does seem like it could be important.
I don't think this is new; did a couple of searches and it seems to have been a study done in 2013.
But there's this:http://gaia-health.com/conventional-medicine/pharmaceuticals/study-claims-cfsme-cause-found-really/

"A new study, financed by Eli Lilly & Forest Labs, claims to have found the cause of fibromyalgia, along with proposing a treatment. The claim falls flat on examination, but Eli Lilly & Forest Labs now have a pathway to reinvent old drugs for a new disease—so they can repatent the drugs!"
 

CFS_for_19_years

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Here's the original study:
Excessive peptidergic sensory innervation of cutaneous arteriole-venule shunts (AVS) in the palmar glabrous skin of fibromyalgia patients: implications for widespread deep tissue pain and fatigue.
https://www.ncbi.nlm.nih.gov/pubmed/23691965
Albrecht PJ1, Hou Q, Argoff CE, Storey JR, Wymer JP, Rice FL.
Abstract
OBJECTIVE:
To determine if peripheral neuropathology exists among the innervation of cutaneous arterioles and arteriole-venule shunts (AVS) in fibromyalgia (FM) patients.

SETTING:

Cutaneous arterioles and AVS receive a convergence of vasoconstrictive sympathetic innervation, and vasodilatory small-fiber sensory innervation. Given our previous findings of peripheral pathologies in chronic pain conditions, we hypothesized that this vascular location may be a potential site of pathology and/or serotonergic and norepinephrine reuptake inhibitors (SNRI) drug action.

SUBJECTS:

Twenty-four female FM patients and nine female healthy control subjects were enrolled for study, with 14 additional female control subjects included from previous studies. AVS were identified in hypothenar skin biopsies from 18/24 FM patient and 14/23 control subjects.:thumbdown::whistle::confused:

METHODS:

Multimolecular immunocytochemistry to assess different types of cutaneous innervation in 3 mm skin biopsies from glabrous hypothenar and trapezius regions.

RESULTS:

AVS had significantly increased innervation among FM patients. The excessive innervation consisted of a greater proportion of vasodilatory sensory fibers, compared with vasoconstrictive sympathetic fibers. In contrast, sensory and sympathetic innervation to arterioles remained normal. Importantly, the sensory fibers express α2C receptors, indicating that the sympathetic innervation exerts an inhibitory modulation of sensory activity.

CONCLUSIONS:

The excessive sensory innervation to the glabrous skin AVS is a likely source of severe pain and tenderness in the hands of FM patients. Importantly, glabrous AVS regulate blood flow to the skin in humans for thermoregulation and to other tissues such as skeletal muscle during periods of increased metabolic demand. Therefore, blood flow dysregulation as a result of excessive innervation to AVS would likely contribute to the widespread deep pain and fatigue of FM. SNRI compounds may provide partial therapeutic benefit by enhancing the impact of sympathetically mediated inhibitory modulation of the excess sensory innervation.
"AVS were identified in hypothenar skin biopsies from 18/24 FM patient and 14/23 control subjects" - it doesn't sound like they studied enough subjects to come to the conclusion that this is a feature of just FM patients since it was also present in so many control subjects.

Full text:
https://academic.oup.com/painmedicine/article-lookup/doi/10.1111/pme.12139
More discussion:
https://www.verywell.com/new-pathology-discovered-in-fibromyalgia-3972942
Here's something to keep in mind about this study: it was funded by two companies that produce fibromyalgia medications - Cymbalta (duloxetine) and Savella (milnacipran.) A press release on the findings mentions that the excess nerves could be why those two drugs work for us, which makes me skeptical about new therapies.

Drug companies aren't in the habit of pursuing new drugs when they can boost sales of the ones already on the market.
 
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Valentijn

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"AVS were identified in hypothenar skin biopsies from 18/24 FM patient and 14/23 control subjects" - it doesn't sound like they studied enough subjects to come to the conclusion that this is a feature of just FM patients since it was also present in so many control subjects.
It sounds like everyone is expected to have AVS, but the FM patients differed in that theirs featured a lot more innervation.