SOD2 A16V mutation and exercise - should antioxidants be used?

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I have a heterozygous mutation on SOD2 A16V (Mitochondria)-Superoxide dismutase. I know this means I will experience more oxidative stress in my mitochondria.

Would it be a good idea to supplement with antioxidants before / after exercise? I realise exercise is beneficial for normal people because it causes stress and so taking antioxidants before exercise would not be a good idea. Especially since a lot of new studies report the negatives of supplementing antioxidants, however I wonder if this mutation means antioxidants are important to limit the amount of oxidative stress?

I know some have used COQ10 to reduce PEM.

Anyone with this mutation or has any theories?
 
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You would have to take antioxidants that get inside the mitochondria. Fusion and fission are important for optimal mitochondria and I'm not sure how those would be impacted.
 

Sherpa

Ex-workaholic adrenaline junkie
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I have this mutation and I respond well to antioxidants. If you want you can always take extra SOD in the form of Extramel melon extract. I don't think it is essential as long as you keep oxadative stress low or take other basic antioxidants (Vitamin C, pycnogenol, astaxanthin, curcumin, Pro-resolving mediators all work well for me).
 
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I have this mutation and I respond well to antioxidants. If you want you can always take extra SOD in the form of Extramel melon extract. I don't think it is essential as long as you keep oxadative stress low or take other basic antioxidants (Vitamin C, pycnogenol, astaxanthin, curcumin, Pro-resolving mediators all work well for me).
Have you taken Seeking Health's SOD supplement?

I've had wonderful effects from working on methylation MTHFR C667T +/-, MTR +/-, MTRR +/- and VDR +/+ after a very, very strong detox reaction to folate so I'm wondering if I took some strong antioxidants even in the form of IVs if it could also have a big impact. I can't seem to tolerate NAC to help with my glutathione as the reaction is incredible strong.
 

Sherpa

Ex-workaholic adrenaline junkie
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Have you taken Seeking Health's SOD supplement?

I've had wonderful effects from working on methylation MTHFR C667T +/-, MTR +/-, MTRR +/- and VDR +/+ after a very, very strong detox reaction to folate so I'm wondering if I took some strong antioxidants even in the form of IVs if it could also have a big impact. I can't seem to tolerate NAC to help with my glutathione as the reaction is incredible strong.
Yes, I've tried the Seeking Health - it's fine. But as I said, nothing I can't live without.

I am +/+ on all the stuff you are +/- on (MTHFR, MTR, MTRR) ! For me the best methylation supplement of all is Methyl Charge+ by Quicksilver Scientific.
 
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I have a heterozygous mutation on SOD2 A16V (Mitochondria)-Superoxide dismutase. I know this means I will experience more oxidative stress in my mitochondria.

Would it be a good idea to supplement with antioxidants before / after exercise? I realise exercise is beneficial for normal people because it causes stress and so taking antioxidants before exercise would not be a good idea. Especially since a lot of new studies report the negatives of supplementing antioxidants, however I wonder if this mutation means antioxidants are important to limit the amount of oxidative stress?

I know some have used COQ10 to reduce PEM.

Anyone with this mutation or has any theories?
I have that mutation ++ GG:sluggish::oh-dear:
I believe this is why hyperbaric oxygen therapy with IV vitamin C helped me.
I also feel better with light therapy - lots of sunlight...although that could be Vitamin D related.

I had no positive response to COQ10, PQQ or MitoQ.

I'm also ++ for two of the VDR snps - bsm and taq. What specifically has helped you address your VDR mutation/s ?
Anne.
 
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I have that mutation ++ GG:sluggish::oh-dear:
I believe this is why hyperbaric oxygen therapy with IV vitamin C helped me.
I also feel better with light therapy - lots of sunlight...although that could be Vitamin D related.

I had no positive response to COQ10, PQQ or MitoQ.

I'm also ++ for two of the VDR snps - bsm and taq. What specifically has helped you address your VDR mutation/s ?
Anne.
Hi Anne,

I was considering hyperbaric oxygen, glad hear you've had good effects from it. How many sessions did you have before you felt a difference?

I take 5000ius per day. Its recommended that you supplement 1000ius per 25lbs of body weight. Previously I was prescribed around 500ius from GP on top of eating plenty of fish, eggs and vitamin D rich foods. It did sod all until I supplemented at a high dose.

Worth noting you should consider taking D3 with a K2 supplement as I believe they work together. You'll be able to find them together in some supplements, I believe NutriLink has one.
 
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Hi Anne,

I was considering hyperbaric oxygen, glad hear you've had good effects from it. How many sessions did you have before you felt a difference?

I take 5000ius per day. Its recommended that you supplement 1000ius per 25lbs of body weight. Previously I was prescribed around 500ius from GP on top of eating plenty of fish, eggs and vitamin D rich foods. It did sod all until I supplemented at a high dose.

Worth noting you should consider taking D3 with a K2 supplement as I believe they work together. You'll be able to find them together in some supplements, I believe NutriLink has one.
I've been supplementing with 5000 iu and vit K2 so I'm probably covered in that regard.
I was reading how some things may help 'activate' the VDR, EG: resveratrol, curcumin, quercetin, zinc, boron, and intense exercise! I'm taking most of those at the moment - ...just not the boron and intense exercise.
I was in an acute situation when I started HBOT (active toxoplasmosis affecting the optic nerve) and I had a positive response to that situation from the first session. My doctor was clear though - he was was treating cellular respiration and not the infection directly. I had several rounds of approx 5 consecutive days HBOT in a hard chamber with 45 g IV vitamin C given just before each dive. I'd had ME 10 + years at that point and my ME symptoms improved across the board.
Soft chamber HBOT is much more accessible here now and I'm not sure how that compares with what I did back in the late 90s. There may be some good HBOT threads here if you do a search, with discussion of more recent treatments.