I think i have slow COMT, here's my results on genetic genie
I have looked into the slowCOMT supplements on seeking health
https://www.seekinghealth.com/collections/dirty-genes-comt-slow-support
but i haven't bought any from there due to not dealing well with magnesium glycinate and being in canada - border issues and such.
i have tried several of the other supplements from other sources though, and ultimately find magnesium malate helps with restless legs, taurine and theanine help with anxiety, NAC has been quite helpful for brain fog and my spine pain and did give me a small improvement in my ME function. I am just about to try SAMe and the step after that will be to try
DIM + I3C,
Calcium-D-Glucarate and
Liver Nutrients (though i have already tried milk thistle and ALA and got nothing but as i said NAC was helpful, i wonder if i took all these together it might be a better effect). Ultimately though, none of the supplements i've tried so far have made much of an impact in my functional level, its more about managing some of the symptoms.
the only thing that has given me any improvement (only temporary whilst i take it) worth talking about is ritalin but i have to pulse it 2 days on 1 day off otherwise it starts causing the issues i'm trying to fix - i wonder if it's cos my dopamine gets too high - i am not sure that the improvement with ritalin is linked with my COMT gene, i think it's more to do with having lax bloodvessels, and the ritalin helps constrict them, but maybe COMT influences that, i don't know.