https://newatlas.com/health-wellbeing/mechanism-links-sleep-regulation-alzheimers-protein-perk/
The article is about Alzheimer's rather than ME, but the findings could apply to ME too. PERK is a signalling pathway that can affect sleep.
A quick check found this paper: https://www.jbc.org/content/291/30/15830.full which is about PERK's effects on the brain's immune system. It seems very technical, so I'm not going to delve deeply into it. However, anything that affects the brain's immune system (and sleep function) is a possible part of ME.
The article is about Alzheimer's rather than ME, but the findings could apply to ME too. PERK is a signalling pathway that can affect sleep.
A quick check found this paper: https://www.jbc.org/content/291/30/15830.full which is about PERK's effects on the brain's immune system. It seems very technical, so I'm not going to delve deeply into it. However, anything that affects the brain's immune system (and sleep function) is a possible part of ME.