Per Kristian Eide,
Vegard Vinje,
Are Hugo Pripp,
Kent-Andre Mardal,
Geir Ringstad
Brain, Volume 144, Issue 3, March 2021, Pages 863–874,
https://doi.org/10.1093/brain/awaa443
Published:
23 March 2021
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Abstract
...
One night of sleep deprivation impaired clearance of the tracer substance from most brain regions, including the cerebral cortex, white matter and limbic structures, as demonstrated on the morning of Day 2 after intervention (sleep deprivation/sleep).
Moreover, the impaired cerebral clearance in the sleep deprivation group was not compensated by subsequent sleep from Day 2 to 3. The present results provide
in vivo evidence that one night of total sleep deprivation impairs molecular clearance from the human brain, and that humans do not catch up on lost sleep
