Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome (Sato et al., 2021)

[SlamDancin]

Wakiro Sato, Hirohiko Ono, Takaji Matsutani, Masakazu Nakamura, Isu Shin, Keiko Amano, Ryuji Suzuki, Takashi Yamamura,
Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome,
Brain, Behavior, and Immunity,
2021

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterized by fatigue and post-exertional malaise, accompanied by various signs of neurological and autonomic dysfunction. ME/CFS is often triggered by an infectious episode and associated with an aberrant immune system. Here we report that ME/CFS is a disorder characterized by skewed B cell receptor gene usage. By applying a next-generation sequencing to determine the clone-based IGHV/IGHD/IGHJ repertoires, we revealed a biased usage of several IGHV genes in peripheral blood B cells from ME/CFS patients. Results of receiver operating characteristic (ROC) analysis further indicated a possibility of distinguishing patients from healthy controls, based on the skewed B cell repertoire. Meanwhile, B cell clones using IGHV3-30 and IGHV3-30-3 genes were more frequent in patients with an obvious infection-related episode at onset, and correlated to expression levels of interferon response genes in plasmablasts. Collectively, these results imply that B cell responses in ME/CFS are directed against an infectious agents or priming antigens induced before disease onset.

https://www.sciencedirect.com/science/article/pii/S0889159121001537?via=ihub

 

[Pyrrhus]

Thanks for sharing this paper, it sounds interesting!

Do you have a link to the paper?

Can you edit the thread title to include the author and year:
https://forums.phoenixrising.me/thr...supportive-and-safe.41752/page-2#post-2327708

Thanks!

 

[SlamDancin]

If anyone could get the full paper I’d appreciate it!

 

[Pyrrhus]

If anyone could get the full paper I’d appreciate it!

Elsevier (sciencedirect.com) rarely provides the free full text of their papers, but in this case a pre-proof is available by clicking "Download PDF" at the top of the page.

 

[Pyrrhus]

This appears to be their main point:

IGHV3-30 and IGHV3-30-3 genes were more frequent in patients with an obvious infection-related episode at onset, and correlated to expression levels of interferon response genes in plasmablasts. Collectively, these results imply that B cell responses in ME/CFS are directed against an infectious agent

 

[nerd]

They also found an upregulation/overexpression of IFN-I-inducible genes MX1 and IFI16 (consistent with previous research). This makes viral pathology the most likely causality.

 

[junkcrap50]

Do you have a link to the paper?

If anyone could get the full paper I’d appreciate it!

Have you heard of Sci-Hub? They access any and all paywalled scientific articles. To avoid getting shut down, they change the ".com" ending occassionally. https://sci-hub.se/

 

[Consul]

Can the B-cell activation implied here in this paper be a responce to cellular- and protein debris caused by oxidative stress or can B-cells only activate in responce to pathogen derived antigens?