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Silicone breast implants and depression, fibromyalgia and chronic fatigue syndrome


Clin Rheumatol. 2019 Jan 31. doi: 10.1007/s10067-019-04447-y. [Epub ahead of print]
Silicone breast implants and depression, fibromyalgia and chronic fatigue syndrome in a rheumatology clinic population.
Khoo T1, Proudman S2,3, Limaye V2,3.
Author information

Silicone breast implants (SBI) may induce systemic autoimmune disease as part of autoimmune syndrome induced by adjuvants (ASIA). This syndrome bears similarities to fibromyalgia and chronic fatigue syndrome (CFS). We sought to determine whether there are any associations between SBI and depression, fibromyalgia and CFS in a rheumatology clinic population.

The electronic files of rheumatology clinic patients at the Royal Adelaide Hospital between 2000 and 2017 were searched for patients who had received SBI prior to rheumatological diagnosis. Demographics, diagnosis, implant history and whether the patient had depression, fibromyalgia or CFS were recorded. Controls were rheumatology clinic patients, half of whom had systemic sclerosis (SSc) and the other half had systemic lupus erythematosus (SLE). They were matched to cases 3:1 for age (within 2 years) and gender.

Thirty patients had received SBI (mean age 47.9, 100% female). Twelve had a diagnosis of depression, 6 of fibromyalgia and 3 of CFS. Implant rupture was not associated with any of these (p = 1). There was no difference in the incidence of depression (p = 1), fibromyalgia (p = 0.76) or CFS (p = 0.3) between cases and SLE controls. When compared with SSc controls, there were significantly more patients with fibromyalgia and/or CFS in the case group (20.0% of cases vs 2.2% of SSc controls, p = 0.01) but no difference in depression (p = 0.12).

Fibromyalgia and CFS are more common in patients with silicone implants than SSc controls but not SLE controls. Prospective study of development of depression, fibromyalgia and CFS in recipients of SBI is required.

Adjuvants; Breast implants; Chronic fatigue syndrome; Depression; Fibromyalgia; Silicone






sample size of this one study is a bit too small but they are not the first to see the pattern.


Senior Member
sample size of this one study is a bit too small but they are not the first to see the pattern.

what are adjuvants?

are the results the same for silicone AND saline implants?

I don't have implants, but if I ever got breast cancer, I would def want reconstruction...


Senior Member

Some clips:

Of the 2 million women in the United States who have had silicone implants over the past 11 years, 100,000 have had them permanently removed in the past 4 years, to alleviate a multitude of grievous ailments.

Patients suffering from chronic fatigue syndrome (CFS)/myalgic encephalomyelitis have pervasive metabolic abnormalities has led to a dramatic shift in efforts to identify mechanisms of disease causation.1,2 The complexity of the metabolic abnormalities is daunting, as they involve mitochondrial dysfunction, epigenetic factors, microbiota, cell membrane permeability, leukocyte respiration, enzymatic reactions, substrate availability, the central nervous system, the autonomic nervous system, adenosine triphosphate (ATP) production in muscle, oxidative phosphorylation, central sensitization, matrix macromolecules, endocrine receptor activity, and routine levels of metabolites

Silicone gel–filled breast implant toxicity provides a model that can inform CFS research; SBIT is mediated by multiple disruptions of the body’s biochemistry that are virtually identical to observations in CFS.