The greatest improvement I've had with any single treatment for ME, was Rifaximin (although I had improvement with LDN and Equilibrant for some months prior). On Day 10 of my first course of Rifaximin, I felt unchained by this disease. It didn't mean I had energy to do crazy aerobic activity, but I could do light activity without feeling horrible and a significant reduction in brain fog.
I then did an 8 wk course of herbal treatment (Candibactin AR/BR) and was miserable...definitely slid back with energy, time in bed, and increased brain fog.
I recently started on a course of Flagyl and Rifaximin. I had to drop the Flagyl after one week because side effects were intolerable (nausea, no appetite, flu-like, hypersominia, brain fog, metallic taste in mouth, and vomiting). I felt better calming in my GI after 24 hours of starting treatment. At this time, I'm still on the Rifaximin and feeling an upward trend in my health again.
I've also commenced on a ketogenic diet. So far it's good with my gut and some bonus weight loss (I need to lose about 20 lbs. that came on quickly during my relapse).