As someone who has tried virtually every class of anti-depressant treatment, plus about every supplement and lifestyle hack you can think of, with the lone exception of 1950s-style irreversible MAOis or any neuroleptics, both before and after the distinct dividing line of developing chronic fatigue with PEM features.
I can say that the only medication that made a tangible difference is Tianeptine. The problems with Tianeptine are that it is a lot more expensive to obtain in bulk quantities than in the past (I need 60-80mg a day to make a diffrence), and it isn't really a sustainable solution for me due to ultimately making the symptoms, which it initially improves, worse after 2-3 months. I also get similar benefit and relief of fatigue and dysautonomic issues from narcotic opioids like hydrocodone or very-low dose oxycodone. Of course, good luck getting opioids these days from a legitimate source, with or without such a compelling argument.
All of the other, more typical or off-label AD medications, including things like Lamotrigine, Selegiline, Tramadol, buproprion, or fluoxetine, which are assumed to be "activating," have too much of an undesirable side effect:benefit ratio. The normal go-to TCAs, serotonergics, or atypicals like lithium, DXM/Ketamine or Mirtazapine induce too much apathy and zombiness for me.
I'm pretty convinced that, in general, whether CFS/ME or not, the people who respond favorably to ADs are those people who either have an anxiety disorder, or a non-chronic, relatively short-origin depression - in which case, it's arguable the "benefit" of medication could just be conflated with spontaneous remission of the short-lived depression episode. I am more of a decades-long dysthymia type, and persistent/chronic depression is an entirely different animal than depression secondary to anxiety disorders or short-term-origin depression episodes.