Regarding manipulating circuits, it does remind me a bit of existing approaches like DNRS or Gupta. These kind of approaches have been trialed by a large number of patients, without any huge success reported. And then there's the more general CBT of course, which could also be seen as manipulating circuits, depending on how you define it. I'm a bit afraid it will open the doors again for all kinds of random vague treatments, if the conclusion is that no drug is worth developing. I can already see the BPS crowd screaming "told you so".
I'm wondering what other serious diseases can be cured simply by "manipulating circuits", because I can't think of any. Well, I hope I'm wrong in my skepticism and that it would really work.