Ruxolitinib (JAK1 JAK2 inhibitor): remarking results on intestinal inflammation

Aubry

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854652/#!po=31.3333

C respresents inflamed dentric cells of the gut before and after administration of Ruxolitinib (the purple grapes are inflamed cells). This is causing probably the abnormalities seen in the micro biome of all ME/CFS patients.Since the micro biome is more and more investigated this could be very interesting for ME/CFS as well. Prof. Meirleir will start trials in 2018 with Filgotinib (another JAK inhibitor) in his patient groups.


Skin and intestinal GvHD responds to ruxolitinib
 

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tyson oberle

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854652/#!po=31.3333

C respresents inflamed dentric cells of the gut before and after administration of Ruxolitinib (the purple grapes are inflamed cells). This is causing probably the abnormalities seen in the micro biome of all ME/CFS patients.Since the micro biome is more and more investigated this could be very interesting for ME/CFS as well. Prof. Meirleir will start trials in 2018 with Filgotinib (another JAK inhibitor) in his patient groups.


Skin and intestinal GvHD responds to ruxolitinib
 

tyson oberle

Senior Member
Messages
126
Likes
93
Location
tampa, florida
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854652/#!po=31.3333

C respresents inflamed dentric cells of the gut before and after administration of Ruxolitinib (the purple grapes are inflamed cells). This is causing probably the abnormalities seen in the micro biome of all ME/CFS patients.Since the micro biome is more and more investigated this could be very interesting for ME/CFS as well. Prof. Meirleir will start trials in 2018 with Filgotinib (another JAK inhibitor) in his patient groups.


Skin and intestinal GvHD responds to ruxolitinib
So did Dr De Meirleir start trials yet with Filgotinib?
 

Daffodil

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so i think the HIV-related cognitive impairment probably has similar cause to our cognitive impairment. i did a google search and found that they are looking at Ruxolitinib (JAK inhibitor) as a potential treatment for HIV-cognitive impairment. I contacted a scientist, who told me some animal results look promising.

I think this is very good news for us!