Ron Davis Talk: Quest for an ME/CFS Diagnostic Test, Columbia Univ, Nov 21, 2019 Livestream

[Gemini]

 

[Peterz]

Why do we have to login to see the picture?

 

[Gemini]

Why do we have to login to see the picture?

@Peterz, not quite sure what you mean? Perhaps a moderator can help?

To view the live presentation by Ron Davis go to the above link at the time noted for your Time Zone:

 

[ljimbo423]

This is playing right now in the Eastern time zone USA.
https://einsteinmed.zoom.us/j/746120765

 

[ljimbo423]

Ron Davis- ME/CFS "has a lot of similarities with sepsis". Blood deformability is one.

 

[percyval577]

Ron Davis- ME/CFS "has a lot of similarities with sepsis". Blood deformability is one.

I am not a fan of the approach "Infection", however, just today has been published:

https://www.frontiersin.org
[ME/CFS] as a hyper-regulated immune-system driven by interplay between reglatory T cells and chronic herpesvirus infections Sepúlveda et al

 

[Sing]

I listened to the whole thing and found it an excellent talk and update from Dr. Davis.

 

[ljimbo423]

I am not a fan of the approach "Infection", however, just today has been published:

Just to be clear, Ron's not saying that ME/CFS is sepsis. He is saying there are a lot of "similarities" to the biological process of sepsis.

 

[Gemini]

Ron Davis- ME/CFS "has a lot of similarities with sepsis". Blood deformability is one.

@ljimbo423 and interesting that Ron linked the cause of the RBC deformability to something in the plasma in this talk.

 

[jstefl]

I watched the talk which is pretty much of a rehash of what he has previously presented. What I came away with is this is a much more difficult problem than what he thought it was a couple of years ago. At one time he was hoping for a quick resolution, but now it seems that the more they learn, the more difficult to understand the disease is.

He mentioned again that they looked for a viral cause and haven't found one yet.

He talked about potential treatments and mentioned that if they can't find an approved drug that works it will take 20 years and a billion dollars to get one.

My take away from the talk is that a cure, or at least a treatment for this illness is farther away than I was hoping for. I will keep hoping for the best and expecting little.

 

[JES]

They already have identified a response in the nanoneedle from copaxone, SS-31 and suramin, so why not start with those?

 

[ljimbo423]

@ljimbo423 and interesting that Ron linked the cause of the RBC deformability to something in the plasma in this talk.

Listening to Ron I got the very clear impression that he thinks that whatever is causing the mito. dysfunction is in the plasma. Which I think would make a good starting point for looking for whatever that is and trace that back to it's origin.

 

[wabi-sabi]

Will this be on youtube if we missed the livestream?

 

[Rufous McKinney]

He talked about potential treatments and mentioned that if they can't find an approved drug that works it will take 20 years and a billion dollars to get one.

Suggests to me- Continue to receive and experience improvement through Chinese traditional Medicine.

The only thing that helps me.

I won't be around for another 20, most likely.

 

[Gemini]

He mentioned again that they looked for a viral cause and haven't found one yet.

@jstefl I think the key word here is "yet," meaning he's still searching-- and most encouraging-- is about ready to start on the RNA viruses which include enteroviruses long thought to be associated with ME/CFS.

I thought he alluded to a new technology and wondered if he meant VirScan developed at Harvard and recently used by UC San Francisco researchers in an AFM study? Discussed on this thread:

https://forums.phoenixrising.me/thr...s-enterovirus-study.78166/page-2#post-2240308

@Janet Dafoe (Rose49) @Hip

 

[Gemini]

I listened to the whole thing and found it an excellent talk and update from Dr. Davis.

Agree @Sing it was an excellent talk.

Almost 200 people participated on the livestream according to the count at the bottom of the screen, interestingly worldwide from the US, Canada, UK, Germany, France, Finland, and other countries.

During the introduction it was mentioned Ron had just spoken at Princeton University. He's doing an outstanding job of educating and raising awareness.

@Janet Dafoe (Rose49)

 

[Sing]

Listening to Ron I got the very clear impression that he thinks that whatever is causing the mito. dysfunction is in the plasma. Which I think would make a good starting point for looking for whatever that is and trace that back to it's origin.

Yes, he said that this would be a job for the biochemists.

 

[LongMacc]

Listening to Ron I got the very clear impression that he thinks that whatever is causing the mito. dysfunction is in the plasma. Which I think would make a good starting point for looking for whatever that is and trace that back to it's origin.

This was to me the most important takeaway from the talk. The cell impedance graphs were impressive and so was the effect of SS-31 - hopefully that can be implemented/trialed soon and it's mechanism of action with respect to ME/CFS patients understood. The fabrication of new nano-needle measuring chips soon is exciting.

Even though this talk essentially revolved around the increasing complexity of this illness, it is nevertheless further understanding which is always good. the nail capillaries were interesting too as it is the first "visible" thing I've seen in this illness which is so poorly understood.

Ron is one hell of a man and hearing him speak is always a pleasure. A true mediator of the scientific process.

 

[Hopeful1976]

Did he say anything about the ido2 trap? Haven't heard anything from @HTester for ages. Anyone have any updates?

 

[jstefl]

He talked about the IDO2 trap and showed some charts on how it works, but it wasn't anything that he didn't talk about before.

He laid out his goals and step one was to find a biomarker. He placed this as a need before finding a treatment which makes sense to me as it gives you a way of measuring the effectiveness of any treatment. I am sure that most of us have tried many things without knowing if they are working and just need more time, or if they will never help. We are still on step one of his plan.